Tumor microenvironment affects exogenous sodium/iodide symporter expression [PDF]
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
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The extra-thyroidal distribution of sodium iodide symporter [PDF]
Frontiers in EndocrinologyThe intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi +2 more
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The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy [PDF]
EJNMMI Research, 2022 Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by ...
Carolin Kitzberger +15 more
doaj +4 more sources
Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes [PDF]
Molecular Therapy: Oncolytics, 2021 Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful
Rebekka Spellerberg +14 more
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Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]
Molecular Therapy: Oncolytics, 2023 Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba.
Juan Pablo Nicola +1 more
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Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]
Antioxidants, 2023 The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz +2 more
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High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]
EJNMMI Radiopharmacy and Chemistry, 2022 Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev +5 more
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Conserved charged amino acid residues in the extracellular region of sodium/iodide symporter are critical for iodide transport activity [PDF]
Journal of Biomedical Science, 2010 Background Sodium/iodide symporter (NIS) mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be critical for iodide transport in our ...
Liang Ji-An +5 more
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Extracellular vesicles deliver sodium iodide symporter protein and promote cancer cell radioiodine therapy [PDF]
Scientific Reports, 2022 Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability to transport radioiodine for cancer theranostics remains unexplored.
Jin Hee Lee +3 more
doaj +2 more sources
The sodium/iodide symporter is a nitrate transporter in the human salivary gland [PDF]
Redox BiologyRationale: The entero-salivary circulation of inorganic nitrate (NO3−) involves the absorption of dietary nitrate in the gut and active uptake from blood by the salivary glands, leading to a 20-25-fold concentration in saliva.
Gaia Picozzi +9 more
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