High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]
EJNMMI Radiopharmacy and Chemistry, 2022 Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev +5 more
doaj +3 more sources
Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]
Antioxidants, 2023 The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz +2 more
doaj +2 more sources
Tumor microenvironment affects exogenous sodium/iodide symporter expression [PDF]
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
doaj +2 more sources
The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy [PDF]
EJNMMI Research, 2022 Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by ...
Carolin Kitzberger +15 more
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Extracellular vesicles deliver sodium iodide symporter protein and promote cancer cell radioiodine therapy [PDF]
Scientific Reports, 2022 Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability to transport radioiodine for cancer theranostics remains unexplored.
Jin Hee Lee +3 more
doaj +2 more sources
Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]
Molecular Therapy: Oncolytics, 2023 Juan Pablo Nicola +1 more
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The master role of polarized NIS expression in regulating iodine metabolism in the human body [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use ...
Bernadett Lévay +5 more
doaj +1 more source
Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2022 Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang +4 more
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New Directions for Child and Adolescent Development, Volume 2022, Issue 185-186, Page 107-122, November 2022., 2022 Abstract The association of overweight/obesity, and central obesity with thiocyanate (SCN), perchlorate (CIO), and nitrate (NO) in childhood and adolescence is unclear. Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6–19 years) using data from the United States National Health and ...
Qi Jiang, Qin Li
wiley +1 more source
Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]
PLoS ONE, 2014 Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani +8 more
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