Results 91 to 100 of about 10,644 (242)
New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License.[Background]: FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid gland development, as well as for the maintenance of the ...
Fernández, Lara P. +4 more
core +2 more sources
Characterization of the Sodium Iodide Symporter Binding Sites [PDF]
Biophysical Journal, 2015 Sodium iodide symporter (NIS) is a membrane protein responsible for accumulation of iodide (I-) in the thyroid and other organs. This is accomplished through active transports in which the sodium (Na+) gradient provides the driving force. In our approach we attempt to bring together the most recent finding on the NIS homologous systems and shine light ...
Zdravkovic, Igor +3 more
openaire +1 more source
Modular breast and tumor perfusion phantoms for 4D dynamic contrast‐enhanced dedicated breast CT
Medical Physics, Volume 52, Issue 10, October 2025.Abstract Background Tumor heterogeneity presents significant challenges in breast cancer diagnosis and treatment. Four‐dimensional dynamic contrast‐enhanced dedicated breast CT (4D DCE‐bCT) is a novel imaging technique designed to capture contrast agent kinetics with high spatial and temporal resolution, enabling detailed assessment of tumor perfusion ...
Liselot C. Goris +4 more
wiley +1 more source
ChemistryOpen, Volume 14, Issue 10, October 2025.A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M. +4 more
wiley +1 more source
Gut and Liver, 2012 Background/AimsThis study was performed to investigate the correlation of sodium iodide symporter (NIS) expression with the functionality and loss of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in human cholangiocarcinoma ...
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Aims: Anaplastic thyroid cancer(ATC) is one of the most aggressive solid tumors. Mutations in the p53 gene are common in anaplastic thyroid cancer, but the effects of p53 mutations are yet to be elucidated.
Lin Liu +8 more
doaj +1 more source
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer [PDF]
, 2007 Background: The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas.
Capen, Charles C. +5 more
core +2 more sources
The Journal of Pathology, Volume 267, Issue 2, Page 130-141, October 2025.Abstract The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes.
Sylvia L Asa +8 more
wiley +1 more source
EJNMMI Research, 2017 Background Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the new radiotracer (18F-TFB) for ...
Sang Bong Lee +7 more
doaj +1 more source
The NAS Perchlorate Review: Questions Remain about the Perchlorate RfD [PDF]
, 2005 Human exposure to perchlorate is commonplace because it is a contaminant of drinking water, certain foods, and breast milk. The U.S. Environmental Protection Agency (EPA) conducted a perchlorate risk assessment in 2002 that yielded a reference dose (RfD)
Ginsberg, Gary, Rice, Deborah
core +2 more sources