Results 141 to 150 of about 22,963 (277)

The sodium/iodide symporter: State of the art of its molecular characterization

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014
The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and thyroid regulation and its function is widely exploited in the diagnosis and treatment of benign and malignant thyroid diseases.
Darrouzet, Elisabeth, Lindenthal, Sabine, Marcellin, Didier, Pellequer, Jean-Luc, Pourcher, Thierry   +4 more
openaire   +5 more sources

Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.

Cancer Research, 2019
The sodium iodide symporter (NIS) is required for iodide uptake which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer where its ability to transport ...
A. Fletcher, Martin L Read, C. Thornton, D. Larner, V. Poole, Katie Brookes, H. Nieto, Mohammed M Alshahrani, Rebecca J. Thompson, Iňigo Landa, J. Fagin, M. Campbell, K. Boelaert, A. Turnell, V. Smith, C. McCabe   +15 more
semanticscholar   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Homology of pendrin sodium-iodide symporter and apical iodide transporter

Frontiers in Bioscience, 2018
We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins.
Benvenga, Salvatore, Guarneri, Fabrizio
openaire   +4 more sources

Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice

Stem Cell Reports, 2015
Muscular dystrophies are a heterogeneous group of myopathies, characterized by muscle weakness and degeneration, without curative treatment. Mesoangioblasts (MABs) have been proposed as a potential regenerative therapy.
Bryan Holvoet, Mattia Quattrocelli, Sarah Belderbos, Lore Pollaris, Esther Wolfs, Olivier Gheysens, Rik Gijsbers, Jeroen Vanoirbeek, Catherine M. Verfaillie, Maurilio Sampaolesi, Christophe M. Deroose   +10 more
doaj   +1 more source

Inherited epithelial transporter disorders—an overview [PDF]

, 2018
Summary: In the late 1990s, the identification of transporters and transporter-associated genes progressed substantially due to the development of new cloning approaches such as expression cloning and, subsequently, to the implementation of the human ...
Bergeron, M., Bürzle, M., Hediger, M., Simonin, A.   +3 more
core  

Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system [PDF]

, 2015
A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations.
Annie Lumen, George D. Loizou, Jeffrey W. Fisher, Kevin McNally, Nysia George   +4 more
core   +2 more sources

Follicular Thyroglobulin Suppresses Iodide Uptake by Suppressing Expression of the Sodium/Iodide Symporter Gene [PDF]

, 1999
K. Suzuki
openalex   +1 more source

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj  

Advances in molecular mechanisms of iodine-131 therapy resistance in thyroid carcinoma

Shanghai Jiaotong Daxue xuebao. Yixue ban
Thyroid cancer is the most common malignant tumor of the endocrine system, with differentiated thyroid carcinoma (DTC) accounting for over 90%. Most DTC patients have a good prognosis after systematic treatment, but a few develop dedifferentiation of ...
LIU Shiqi, WANG Hui, FENG Fang
doaj   +1 more source