Results 181 to 190 of about 5,274 (210)

The Sodium-Iodide Symporter

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2004
The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
Claire H. Baker, John C. Morris
openaire   +3 more sources

Sodium/iodide symporter in thyroid cancer

Experimental and Clinical Endocrinology & Diabetes, 2001
[No abstract available]
C. Mian, L. Lacroix, J. M. Bidart, B. Caillou, FILETTI, SEBASTIANO, M. Schlumberger   +5 more
openaire   +5 more sources

Sodium Iodide Symporter in Health and Disease

Thyroid, 2001
Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy.
Richard T. Kloos, Sissy M. Jhiang, Daniel H. Y. Shen, Ernest L. Mazzaferri   +3 more
openaire   +3 more sources

Cloning of the Mouse Sodium Iodide Symporter

Thyroid, 2001
The iodide-concentrating ability of the thyroid gland is essential to the production of thyroid hormone. We report the nucleotide and amino acid sequence of the mouse sodium iodide symporter (mNIS), which mediates this activity within the thyroid gland.
Charyl M. Dutton, Diana S. Dean, Lori A. Pinke, Elizabeth R. Bergert, John C. Morris, Christine Spitzweg   +5 more
openaire   +2 more sources

Approaches to gene therapy with sodium/iodide symporter

Experimental and Clinical Endocrinology & Diabetes, 2001
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy.
John C. Morris, Christine Spitzweg
openaire   +3 more sources

Expression of the Sodium/Iodide Symporter in Human Prostate Adenocarcinoma

Urology, 2010
To analyze expression of the sodium/iodide symporter (NIS) in tissue specimen from a large series of patients with prostate adenocarcinoma. Few data are available on the NIS expression in prostate tumor tissues.NIS protein expression was examined by immunohistochemistry in 78 tumor tissue specimen and their non-neoplastic counterparts.
M. Navarra, MICALI, Salvatore, SM lepore, AM Cesinaro, M. Celano, MC Sighinolfi, C. De Gaetani, S. Filetti, BIANCHI, Giampaolo, D. Russo   +9 more
openaire   +4 more sources

Clinical Relevance of the Thyroid Sodium/Iodide Symporter [PDF]

, 2003
The first step in the formation of thyroid hormones (TH) involves the active accumulation of iodide from the extracellular fluid across the basolateral membrane and into the thyroid follicular cell. The protein responsible for this was previously described as the iodide trap or iodide pump.
Peter H. K. Eng, Su-Chin Ho
openaire   +1 more source

Sodium/iodide symporter (NIS) and cytokines

Experimental and Clinical Endocrinology & Diabetes, 2001
It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1beta and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells.
openaire   +3 more sources

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid, 2017
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.The study employed ...
Peter J. Nelson, Peter Bartenstein, Ernst Wagner, Christina Schug, Patrick Dolp, Kerstin Knoop, Nathalie Schwenk, Kathrin A Schmohl, Manfred Ogris, Kathrin Klutz, Christine Spitzweg   +10 more
openaire   +4 more sources

Implications of the molecular characterization of the sodium-iodide symporter (NIS)

Experimental and Clinical Endocrinology & Diabetes, 2009
The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient. This uptake requires energy, is coupled to the action of Na+/K+-ATPase, and stimulated by TSH, the main hormone regulating thyroid-specific ...
Josef Köhrle, Cornelia Schmutzler
openaire   +3 more sources