Results 11 to 20 of about 13,985 (144)
Scientific Reports, 2022 Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability to transport radioiodine for cancer theranostics remains unexplored.
Jin Hee Lee +3 more
semanticscholar +1 more source
Evolutionary Applications, 2022 The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function
Ann M. Petersen +9 more
semanticscholar +1 more source
Anion Selectivity by the Sodium Iodide Symporter [PDF]
Endocrinology, 2003 Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline +6 more
openaire +2 more sources
Cancers, 2022 Simple Summary Most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis. However, a significant number progress to advanced disease exhibiting aggressive clinical characteristics.
Márcia Faria +5 more
semanticscholar +1 more source
The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.
Endocrine-Related Cancer, 2021 Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy ...
C. Spitzweg +7 more
semanticscholar +1 more source
ACS Nano, 2021 Iodine has shown promise in enhancing radiotherapy. However, conventional iodine compounds show fast clearance and low retention inside cancer cells, limiting their application as a radiosensitizer.
Benjamin Cline +14 more
semanticscholar +1 more source
OncoTargets and Therapy, 2021 Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
T. Anekpuritanang +5 more
semanticscholar +1 more source
Expression of the sodium iodide symporter in human kidney [PDF]
Kidney International, 2001 The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Charyl M. Dutton +6 more
openaire +3 more sources
Thyroid, 2021 BACKGROUND The Hippo pathway has a fundamental role in tissue homeostasis, but little is known about how this signaling cascade is controlled in the thyroid.
C. Fernández-Méndez, P. Santisteban
semanticscholar +1 more source
Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism
Thyroid, 2021 The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.
H. Durgia +7 more
semanticscholar +1 more source