Results 11 to 20 of about 22,988 (277)

Structural insights into the mechanism of the sodium/iodide symporter. [PDF]

open access: yesNature, 2022
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I-) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones-the master regulators of intermediary metabolism. NIS couples the inward translocation of I- against its electrochemical gradient to the inward transport
Ravera S   +7 more
europepmc   +4 more sources

Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]

open access: yesMolecular Therapy: Oncolytics, 2023
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba.
Juan Pablo Nicola   +1 more
doaj   +4 more sources

The extra-thyroidal distribution of sodium iodide symporter [PDF]

open access: yesFrontiers in Endocrinology
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi   +2 more
doaj   +2 more sources

High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]

open access: yesEJNMMI Radiopharmacy and Chemistry, 2022
Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev   +5 more
doaj   +3 more sources

The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAF V600E Mutation. [PDF]

open access: yesOnco Targets Ther, 2021
Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
Anekpuritanang T   +5 more
europepmc   +2 more sources

Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]

open access: yesAntioxidants, 2023
The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz   +2 more
doaj   +2 more sources

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells. [PDF]

open access: yesPLoS One, 2020
The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI ...
Faria M   +5 more
europepmc   +2 more sources

Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma. [PDF]

open access: yesSci Rep, 2020
Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without ...
Rakhsh-Khorshid H   +7 more
europepmc   +2 more sources

Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma. [PDF]

open access: yesMol Ther Oncolytics, 2022
Spellerberg R   +15 more
europepmc   +2 more sources

Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS). [PDF]

open access: yesJ Chem Inf Model, 2020
The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid ...
Zhekova HR   +10 more
europepmc   +2 more sources

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