Sodium Iodide Symporter (NIS) and Thyroid [PDF]
HORMONES, 2002 idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine Spitzweg, John C. Morris
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Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism. [PDF]
Thyroid, 2022 Durgia H +7 more
europepmc +3 more sources
In Vivo Myoblasts Tracking Using the Sodium Iodide Symporter Gene Expression in Dogs [PDF]
Molecular Therapy: Methods & Clinical Development, 2020 Stem cell-based therapies are a promising approach for the treatment of degenerative muscular diseases; however, clinical trials have shown inconclusive and even disappointing results so far.
Isabel Punzón +10 more
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Evolution and developmental expression of the sodium-iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology. [PDF]
Evol Appl, 2022 Petersen AM +9 more
europepmc +2 more sources
Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionuclide Therapy for Glioblastoma. [PDF]
Cancers (Basel)Shah S, Lucke-Wold B.
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The master role of polarized NIS expression in regulating iodine metabolism in the human body [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use ...
Bernadett Lévay +5 more
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Dimerization of the Sodium/Iodide Symporter. [PDF]
Thyroid, 2019 Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson RJ +11 more
europepmc +3 more sources
Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2022 Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang +4 more
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Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]
PLoS ONE, 2014 Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani +8 more
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Frontiers in Endocrinology, 2021 Background and ObjectivesDefects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).
Cao-Xu Zhang +12 more
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