Structural insights into the mechanism of the sodium/iodide symporter. [PDF]
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I-) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones-the master regulators of intermediary metabolism. NIS couples the inward translocation of I- against its electrochemical gradient to the inward transport
Ravera S+7 more
europepmc +4 more sources
Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba.
Juan Pablo Nicola+1 more
doaj +4 more sources
The extra-thyroidal distribution of sodium iodide symporter [PDF]
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi+2 more
doaj +2 more sources
High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]
Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev+5 more
doaj +3 more sources
The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAF V600E Mutation. [PDF]
Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
Anekpuritanang T+5 more
europepmc +2 more sources
Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]
The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz+2 more
doaj +2 more sources
TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells. [PDF]
The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI ...
Faria M+5 more
europepmc +2 more sources
Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma. [PDF]
Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without ...
Rakhsh-Khorshid H+7 more
europepmc +2 more sources
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma. [PDF]
Spellerberg R+15 more
europepmc +2 more sources
Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS). [PDF]
The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid ...
Zhekova HR+10 more
europepmc +2 more sources