Results 191 to 200 of about 5,274 (210)
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Regulation of the sodium/iodide symporter by retinoids - a review
Experimental and Clinical Endocrinology & Diabetes, 2001Decrease or loss of iodide uptake, due to impaired expression and/or function of the sodium/iodide-symporter (NIS), is a major obstacle to the treatment of advanced thyroid carcinomas by radioiodide therapy. Several approaches are being evaluated to optimise or restore sufficient iodide transport in those cases, among them retinoid therapy.
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Small‐Molecule Inhibitors of Sodium Iodide Symporter Function
ChemBioChem, 2008AbstractThe Na+/I− symporter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post‐translational regulation of NIS are still unknown. The purpose of this study was to identify and characterize inhibitors of NIS function.
Roman Lopez +5 more
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Gene therapy with sodium/iodide symporter in hepatocarcinoma
Experimental and Clinical Endocrinology & Diabetes, 2001The ability of thyroid cells to accumulate iodide is a prerequisite for successful radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence
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In vivo imaging and tumor therapy with the sodium iodide symporter
Journal of Cellular Biochemistry, 2003AbstractThere has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and ...
John C. Morris +2 more
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A systematic evaluation of sorting motifs in the sodium–iodide symporter (NIS)
Biochemical Journal, 2016The sodium–iodide symporter (NIS) is an integral membrane protein that plays a crucial role in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its intracellular sorting and distribution have a tremendous effect on its function, and constitute an important aspect of its regulation.
Charles Marchetti +8 more
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Characterization of the upstream enhancer of the rat sodium/iodide symporter gene
Experimental and Clinical Endocrinology & Diabetes, 2001We previously demonstrated the presence of an enhancer that is located between nucleotides - 2264 and - 2495 in the 5' flanking region of the rat sodium/iodide symporter (NIS) gene (Ohno et al., 1999). When attached to NIS or heterologous promoters, this 232 bp fragment, which we call NUE, is able to stimulate transcription in a thyroid-specific and ...
CHUN J. T., DI LAURO, ROBERTO
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Sodium Iodide Symporter in Thyroid Carcinoma
2012Thyroid iodide uptake is essential for the clinical application of radioiodine in patients with well-differentiated thyroid carcinoma. Iodide uptake occurs across the plasma membranes of thyroid follicular cells and cancer cells via an active transporter process mediated by sodium iodide symporter (NIS).
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Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins
Journal of Endocrinological Investigation, 1999We have demonstrated that Na+/I- symporter (NIS), a novel thyroid autoantigen, has local amino acid sequence homologies with the other thyroid autoantigens: Thyroglobulin (Tg), thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R). These homologies concern the 4th, 5th, 6th extracellular loop and the beginning of the intracellular tail.
BENVENGA, Salvatore +3 more
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Sodium Iodide Symporter in the Fight Against Thyroid Cancer
Future Oncology, 2013n radioiodide n signal transduction inhibitor n sodium iodide symporter n thyroid cancer More than 60 years of experience of radioiodide therapy has indicated its usefulness for the treatment of differentiated thyroid cancer. This therapy utilizes the differentiated function of thyroid cells, namely iodide uptake for thyroid hormone synthesis.
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Cloning of the Human Sodium Iodide Symporter
Biochemical and Biophysical Research Communications, 1996The iodide concentrating activity of the thyroid gland is essential to the production of thyroid hormone and also provides a mechanism for the treatment of thyroid cancer by radioiodine ablation. We report here the nucleotide and amino acid sequence of the human sodium iodide symporter (hNIS), which mediates the iodide uptake activity in the thyroid ...
Patricia A. Smanik +6 more
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