Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS). [PDF]
J Chem Inf Model, 2020 The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid ...
Zhekova HR +10 more
europepmc +2 more sources
Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells. [PDF]
J Cancer, 2020 Objective: Anaplastic thyroid cancer/ATC is a highly aggressive malignancy with extremely poor prognosis. Resveratrol/Res promotes re-differentiation of cancer cells and exerts inhibitory effects on ATC cells.
Xiong L +6 more
europepmc +2 more sources
Stem Cells Translational Medicine, 2020 Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell‐based cardiac therapies.
John W. Ostrominski +20 more
doaj +2 more sources
Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes. [PDF]
Mol Ther Oncolytics, 2021 Spellerberg R +14 more
europepmc +2 more sources
Sodium Iodide Symporter (NIS) and Thyroid [PDF]
HORMONES, 2002 idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine Spitzweg, John C. Morris
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Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition. [PDF]
Arch Toxicol, 2021 Wang J +8 more
europepmc +2 more sources
Post-transcriptional Regulation of the Sodium/Iodide Symporter by Thyrotropin [PDF]
Journal of Biological Chemistry, 2001 The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active I(-) transport in the thyroid gland (Dai, G., Levy, O., and Carrasco, N. (1996) Nature 379, 458-460), the first step in thyroid hormone biogenesis. Whereas relatively little is known about the mechanisms by which thyrotropin (TSH), the main hormonal regulator of ...
Claudia A. Riedel +2 more
openalex +5 more sources
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.
Cell Chem Biol, 2022 Read ML +14 more
europepmc +2 more sources
The sodium iodide symporter: its pathophysiological and therapeutic implications [PDF]
Clinical Endocrinology, 2002 SummaryThe sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and ...
Christine Spitzweg, John C. Morris
openalex +4 more sources
The master role of polarized NIS expression in regulating iodine metabolism in the human body [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use ...
Bernadett Lévay +5 more
doaj +1 more source