Results 21 to 30 of about 5,274 (210)
Expression of the sodium iodide symporter in human kidney [PDF]
Kidney International, 2001 The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Charyl M. Dutton +6 more
openaire +3 more sources
Iodine status in Turkish populations and exposure to iodide uptake inhibitors. [PDF]
PLoS ONE, 2014 Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function.
Aysel Ozpinar +14 more
doaj +1 more source
Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]
Hormones and Cancer, 2014 Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Daniel Scarberry +3 more
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Co-transport-induced instability of membrane voltage in tip-growing cells [PDF]
Phys. Rev. Lett. 95 (2005) 208105, 2005 A salient feature of stationary patterns in tip-growing cells is the key role played by the symports and antiports, membrane proteins that translocate two ionic species at the same time. It is shown that these co-transporters destabilize generically the membrane voltage if the two translocated ions diffuse differently and carry a charge of opposite ...
arxiv +1 more source
New Choice for Small Universal Devices: Symport/Antiport P Systems [PDF]
EPTCS 1, 2009, pp. 235-242, 2009 Symport/antiport P systems provide a very simple machinery inspired by corresponding operations in the living cell. It turns out that systems of small descriptional complexity are needed to achieve the universality by these systems. This makes them a good candidate for small universal devices replacing register machines for different simulations ...
arxiv +1 more source
Characterization of the Sodium Iodide Symporter Binding Sites [PDF]
Biophysical Journal, 2015 Sodium iodide symporter (NIS) is a membrane protein responsible for accumulation of iodide (I-) in the thyroid and other organs. This is accomplished through active transports in which the sodium (Na+) gradient provides the driving force. In our approach we attempt to bring together the most recent finding on the NIS homologous systems and shine light ...
Sergei Y. Noskov +3 more
openaire +2 more sources
Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology [PDF]
Endocrinology and Metabolism, 2014 Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of
June-Key Chung, Gi Jeong Cheon
doaj +1 more source
International Journal of Endocrinology, 2018 Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao +7 more
doaj +1 more source
Expression of sodium-iodide symporter in thyroid gland tumors: immunohistochemical study [PDF]
Морфологія, 2009 One of the key moments of radioiodine therapy, and also radioisotope diagnostics of cancers of a thyroid gland is ability of their cells to accumulate iodide.
Bondarenko O.O. +2 more
doaj
Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid
World Journal of Nuclear Medicine, 2012 Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana +3 more
doaj +1 more source