Translational Research Using Sodium/Iodide Symporter [PDF]
Journal of Korean Endocrine Society, 2006 184 1915년에 갑상선 조직에 요오드가 선택적으로 축적된다 는 사실이 밝혀졌고, 그 이후 갑상선 질환의 진단과 치료에 방사성요오드가 널리 이용되게 되었다. 갑상선 조직은 요오 드를 혈액에서부터 20~40배 정도 높은 농도로 축적한다. 약 60년 전부터 방사성요오드를 갑상선 기능을 측정하는 추적 자로 사용하였고, 곧이어 갑상선기능항진증과 갑상선암에서 I-131를 치료제로 사용하게 되었다. 그러나 갑상선 세포에 요오드가 선택적으로 섭취되는 기 전은 최근에야 밝혀졌다.
June-Key Chung, Joo Hyun Kang
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Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy [PDF]
Endocrinology and Metabolism, 2019 The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk
Jierui Liu +3 more
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Iodine status in Turkish populations and exposure to iodide uptake inhibitors. [PDF]
PLoS ONE, 2014 Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function.
Aysel Ozpinar +14 more
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Anion Selectivity by the Sodium Iodide Symporter [PDF]
Endocrinology, 2003 Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline +6 more
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Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]
, 2010 Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques +6 more
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Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
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Stem Cell Research, 2019 Primary hepatocyte transplantation (HTx) is a safe cell therapy for patients with liver disease, but wider application is circumvented by poor cell engraftment due to limitations in hepatocyte quality and transplantation strategies. Hepatocyte-like cells
Candice Ashmore-Harris +6 more
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Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]
, 2016 Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad +46 more
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Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate [PDF]
, 2005 Perchlorate has been detected in groundwater in many parts of the United States, and recent detection in vegetable and dairy food products indicates that contamination by perchlorate is more widespread than previously thought.
Fowler, Bruce A. +4 more
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