Results 31 to 40 of about 22,819 (283)

Dimerization of the Sodium/Iodide Symporter. [PDF]

Thyroid, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NHF, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ.   +11 more
europepmc   +4 more sources

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Theranostics, 2021
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane,
J. Oh, B. Ahn
semanticscholar   +1 more source

Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]

Endocrinology and Metabolism, 2022
Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang, Eun Kyung Lee, Jeonghee Lee, Yul Hwangbo, Jeongseon Kim   +4 more
doaj   +1 more source

Mesenchymal Stem Cell-mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice.

Clinical Cancer Research, 2022
PURPOSE Mesenchymal stem cells (MSCs) have emerged as cellular-based vehicles for the delivery of therapeutic genes in cancer therapy based on their inherent tumor homing capability.
Carolin Kitzberger, Rebekka Spellerberg, Yang Han, Kathrin A Schmohl, Christina Stauss, C. Zach, R. Kälin, G. Multhoff, Mathias Eiber, F. Schilling, R. Glass, W. Weber, E. Wagner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]

PLoS ONE, 2014
Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani, Ines Bucci, Serena Di Santo, Cosmo Rossi, Antonino Grassadonia, Marianna Mariotti, Mauro Piantelli, Fabrizio Monaco, Giorgio Napolitano   +8 more
doaj   +1 more source

Anion Selectivity by the Sodium Iodide Symporter [PDF]

Endocrinology, 2003
Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline, Massart, Claude, Beauwens, Renaud, Schoutens, André, Costagliola, Sabine, Dumont, Jacques Emile, Wolff, J   +6 more
openaire   +2 more sources

Novel Compound Heterozygous Pathogenic Mutations of SLC5A5 in a Chinese Patient With Congenital Hypothyroidism

Frontiers in Endocrinology, 2021
Background and ObjectivesDefects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).
Cao-Xu Zhang, Jun-Xiu Zhang, Liu Yang, Chang-Run Zhang, Feng Cheng, Rui-Jia Zhang, Ya Fang, Zheng Wang, Feng-Yao Wu, Pei-Zhang Li, Jun Liang, Rui Li, Huai-Dong Song   +12 more
doaj   +1 more source

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.

Endocrine-Related Cancer, 2021
Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy ...
C. Spitzweg, P. Nelson, E. Wagner, P. Bartenstein, W. Weber, M. Schwaiger, J. Morris, Christopher John McCabe   +7 more
semanticscholar   +1 more source

Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy [PDF]

Endocrinology and Metabolism, 2019
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk
Jierui Liu, Yanqing Liu, Yansong Lin, Jun Liang   +3 more
doaj   +1 more source

Equilibrium Properties of E. coli Lactose Permease Symport -- A Random-walk Model Approach [PDF]

, 2021
The symport of lactose and H+ is an important physiological process in E. coli, for it is closely related to cellular energy supply. In this paper, the symport of H+ and lactose by E. coli LacY protein is computationally simulated using a newly proposed cotransport model that takes the "leakage" phenomenon (uncoupled sugar translocation) into account ...
arxiv   +1 more source