Results 31 to 40 of about 5,274 (210)

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

Nature Communications, 2018
Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri, Julie Foster, Roxana Kashani, Patrycja Gazinska, Celia Cook, Jane Sosabowski, John Maher, Sophie Papa   +7 more
doaj   +1 more source

Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland [PDF]

Thyroid, 2013
Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia. NIS expression at
Adam Bobbey, Nathan Hall, Rebecca Nagy, Amy Lehman, Paul E. Wakely, Sissy M. Jhiang, Krista M. D. La Perle, David Jarjoura, Daniel H. Shen, Dong Chul Kim   +9 more
openaire   +3 more sources

Effect of Mutations on Transport by the Sodium/Iodide Symporter (NIS) [PDF]

Biophysical Journal, 2015
The Na+/I- symporter (NIS) mediates iodide transport into the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. To understand the observed effects of single amino acid substitutions in the mechanism of transport by NIS, wild type NIS and NIS mutated at selected positions were studied using computational
L. Mario Amzel, Yuly E. Sánchez, Yuly E. Sánchez, Juan Pablo Nicola, Giuseppe Ferrandino, Nancy Carrasco   +5 more
openaire   +2 more sources

Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails

Anais da Academia Brasileira de Ciências
The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO, ALBA C.M. SILVA, IRACEMA G. ARAUJO, VICTOR M. TUNHOLI, VINÍCIUS M. TUNHOLI-ALVES, ROSANE N. CASTRO, DENISE P. CARVALHO, JAIRO PINHEIRO, MICHELLE P. MARASSI   +8 more
doaj   +1 more source

Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma [PDF]

Nuclear Medicine and Molecular Imaging, 2010
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).
Ho-Young Lee, Joo Hyun Kang, Keon Wook Kang, Hyewon Youn, June-Key Chung   +4 more
openaire   +3 more sources

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Charles J. Link, Nick Vahanian, Erica Roberson, Tatiana Seregina, Robert C. Unfer, Wayne Daniels, Elena Mitrofanova, Prem Seth   +7 more
openaire   +3 more sources

General Principles of Secondary Active Transporter Function [PDF]

, 2019
Transport of ions and small molecules across the cell membrane against electrochemical gradients is catalyzed by integral membrane proteins that use a source of free energy to drive the energetically uphill flux of the transported substrate. Secondary active transporters couple the spontaneous influx of a "driving" ion such as Na$^+$ or H$^+$ to the ...
arxiv   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

PTTG and PBF repress the human sodium iodide symporter [PDF]

Oncogene, 2007
The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most thyroid tumours exhibit reduced iodide uptake, although the mechanisms accounting for this remain poorly understood.
Kristien Boelaert, Margaret C. Eggo, T Kogai, Vicki Smith, Jayne A. Franklyn, John Watkinson, L Tannahill, AL Stratford, Christopher McCabe   +8 more
openaire   +3 more sources

Hubungan Ekspresi Sodium Iodide Symporter dengan Varian Histopatologi dan Stadium Papillary Thyroid Carcinoma

Majalah Kedokteran Andalas
Abstrak                                                               Tujuan:  Mengetahui hubungan ekspresi sodium iodide symporter dengan varian histopatologi dan stadium papillary thyroid carcinoma.
Rini Purnama Sari, yenita - yenita, Noza - Hilbertina, tofrizal - tofrizal, Daan - Khambri, Husna - Yetti   +5 more
doaj   +1 more source