Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology [PDF]
Endocrinology and Metabolism, 2014 Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of
June-Key Chung, Gi Jeong Cheon
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Functional characterization of human thyroid tissue with immunohistochemistry [PDF]
, 2007 Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases.
Bernard, Caillou +6 more
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International Journal of Endocrinology, 2018 Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao +7 more
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Sodium iodide symporter (NIS) in extrathyroidal malignancies: Focus on breast and urological cancer [PDF]
, 2014 BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia ...
BIANCHI, Giampaolo +8 more
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S-nitrosylation of NF-kB p65 inhibits TSH-induced Na+/I- symporter expression [PDF]
, 2015 Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces thyrotropin (TSH)-stimulated thyroid specific gene expression ...
Bocco, Jose Luis +8 more
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Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]
Hormones and Cancer, 2014 Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Aparna, Lakshmanan +3 more
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Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid
World Journal of Nuclear Medicine, 2012 Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana +3 more
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HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]
, 2014 Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D +4 more
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Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Nature Communications, 2018 Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri +7 more
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Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]
, 2013 Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K. +12 more
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