Results 41 to 50 of about 10,644 (242)

MAPK Inhibitors Enhance HDAC Inhibitor-Induced Redifferentiation in Papillary Thyroid Cancer Cells Harboring BRAFV600E: An In Vitro Study

Molecular Therapy: Oncolytics, 2019
Clinical efficacy of redifferentiation therapy with histone deacetylase inhibitor (HDACi) for lethal radioiodine-refractory papillary thyroid cancer (RR-PTC) is urgently needed to be improved.
Hao Fu, Lingxiao Cheng, Yuchen Jin, Lin Cheng, Min Liu, Libo Chen   +5 more
doaj   +1 more source

Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression [PDF]

, 2015
Purpose Down-regulation of thyroid hormone receptor beta (THRβ) gene has been described in several human malignancies, including thyroid cancer. In this study, we analyzed THRβ mRNA expression in surgical specimens from a series of human papillary ...
Celano, M, D'Agostino, M, DI GIOIA, Cira Rosaria Tiziana, Dima, Mariavittoria, Durante, Cosimo, Giacomelli, Laura, Maggisano, V, Pecce, Valeria, Rosignolo, Francesca, Sponziello, Marialuisa, Verrienti, Antonella   +10 more
core   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Expression of the sodium iodide symporter in human kidney [PDF]

Kidney International, 2001
The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Spitzweg, Christine, Dutton, Charyl M., Castro, Maria R., Bergert, Elizabeth R., Goellner, John R., Heufelder, Armin E., Morris, John C.   +6 more
openaire   +2 more sources

Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails

Anais da Academia Brasileira de Ciências
The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO, ALBA C.M. SILVA, IRACEMA G. ARAUJO, VICTOR M. TUNHOLI, VINÍCIUS M. TUNHOLI-ALVES, ROSANE N. CASTRO, DENISE P. CARVALHO, JAIRO PINHEIRO, MICHELLE P. MARASSI   +8 more
doaj   +1 more source

A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression

Molecular Therapy: Oncolytics, 2019
Colon cancer has a high rate of recurrence even with good response to modern therapies. Novel curative adjuncts are needed. Oncolytic viral therapy has shown preclinical promise against colon cancer but lacks robust efficacy in clinical trials and raises
Susanne G. Warner, Sang-In Kim, Shyambabu Chaurasiya, Michael P. O’Leary, Jianming Lu, Venkatesh Sivanandam, Yanghee Woo, Nanhai G. Chen, Yuman Fong   +8 more
doaj   +1 more source

Measles virus causes immunogenic cell death in human melanoma [PDF]

, 2011
Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn, Donnelly, Oliver G, Errington-Mais, Fiona, Hadac, Elizabeth, Harrington, Kevin, Jennings, Victoria, Melcher, Alan A, Pandha, Hardev, Peach, Howard, Phillips, Roger M, Russell, Stephen, Scott, Karen, Selby, Peter, Steele, Lynette, Vile, Richard   +14 more
core   +1 more source

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj   +1 more source

A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]

, 2019
Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J., Domingues, Rita, Faria, Márcia, Félix, Daniela, Matos, Paulo, Silva, Ana L.   +5 more
core   +1 more source

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Elena, Mitrofanova, Robert, Unfer, Nick, Vahanian, Wayne, Daniels, Erica, Roberson, Tatiana, Seregina, Prem, Seth, Charles, Link   +7 more
openaire   +2 more sources