Results 51 to 60 of about 10,644 (242)

Lacrimal duct obstruction after radioiodine therapy: case report and treatment [PDF]

, 2014
Iodotherapy represents the radioactive iodine therapy. The beta radiation emitted by radioactive iodine are particles that will be stored in the thyroid tissue destroying cancer cells that were left after surgery (thyroidectomy).
Lorena, Silvia Helena Tavares, Silva, João Amaro Ferrari   +1 more
core   +3 more sources

Anti-thyroid antibodies: methodological aspects and diagnostic significance [PDF]

, 2003
Since the first publication, more than 40 years ago, laboratory tests for the presence of antibodies (Ab) to thyroid antigens (Ag) have played a pivotal position in the diagnosis of thyroid diseases.
Hauache, Omar M., Kasamatsu, Teresa S., Maciel, Rui Monteiro de Barros, Vieira, José Gilberto H.   +3 more
core   +3 more sources

The sodium iodide symporter: its pathophysiological and therapeutic implications [PDF]

Clinical Endocrinology, 2002
SummaryThe sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and ...
Christine, Spitzweg, John C, Morris
openaire   +2 more sources

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health

Frontiers in Endocrinology, 2022
Thyroid disruptors are found in food, atmosphere, soil, and water. These contaminants interfere with the thyroid function through the impairment of thyroid hormone synthesis, plasma transport, peripheral metabolism, transport into the target cells, and ...
Caroline Serrano-Nascimento, Caroline Serrano-Nascimento, Maria Tereza Nunes   +2 more
doaj   +1 more source

Cardiosphere-derived cells demonstrate metabolic flexibility that Is influenced by adhesion status [PDF]

, 2017
Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs.
Abraham, M. Roselle, Afzal, Junaid, Aon, Miguel A, Chan, Angel, Foster, D. Brian, Guan, Yufan, Karakas, Mehmet Fatih, O\u27Rourke, Brian, Pomper, Martin, Rathmell, Jeffrey, Tsui, Benjamin, Vakrou, Styliani, Wahl, Richard, Woldemichael, Kirubel   +13 more
core   +2 more sources

PTTG and PBF repress the human sodium iodide symporter [PDF]

Oncogene, 2007
The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most thyroid tumours exhibit reduced iodide uptake, although the mechanisms accounting for this remain poorly understood.
K, Boelaert, V E, Smith, A L, Stratford, T, Kogai, L A, Tannahill, J C, Watkinson, M C, Eggo, J A, Franklyn, C J, McCabe   +8 more
openaire   +2 more sources

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells [PDF]

, 2016
n this study we analyzed the expression levels of markers of epithelial-to-mesenchymal transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor genotypes and clinicopathological characteristics.
Bulotta, Stefania, Celano, Marilena, Damante, Giuseppe, De Rose, Roberta Francesca, DURANTE, COSIMO, FILETTI, SEBASTIANO, Lombardo, Giovanni Enrico, Maggisano, Valentina, PECCE, VALERIA, ROSIGNOLO, FRANCESCA, Russo, Diego, SPONZIELLO, Marialuisa   +11 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source