Characterization of the Sodium Iodide Symporter Binding Sites [PDF]
Biophysical Journal, 2015 Sodium iodide symporter (NIS) is a membrane protein responsible for accumulation of iodide (I-) in the thyroid and other organs. This is accomplished through active transports in which the sodium (Na+) gradient provides the driving force. In our approach we attempt to bring together the most recent finding on the NIS homologous systems and shine light ...
Sergei Y. Noskov +3 more
openaire +2 more sources
Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]
, 2016 Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad +46 more
core +1 more source
New Choice for Small Universal Devices: Symport/Antiport P Systems [PDF]
EPTCS 1, 2009, pp. 235-242, 2009 Symport/antiport P systems provide a very simple machinery inspired by corresponding operations in the living cell. It turns out that systems of small descriptional complexity are needed to achieve the universality by these systems. This makes them a good candidate for small universal devices replacing register machines for different simulations ...
arxiv +1 more source
Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology [PDF]
Endocrinology and Metabolism, 2014 Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of
June-Key Chung, Gi Jeong Cheon
doaj +1 more source
S-nitrosylation of NF-kB p65 inhibits TSH-induced Na+/I- symporter expression [PDF]
, 2015 Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces thyrotropin (TSH)-stimulated thyroid specific gene expression ...
Bocco, Jose Luis +8 more
core +3 more sources
International Journal of Endocrinology, 2018 Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao +7 more
doaj +1 more source
Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
core +1 more source
Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression [PDF]
, 2015 Purpose Down-regulation of thyroid hormone receptor beta (THRβ) gene has been described in several human malignancies, including thyroid cancer. In this study, we analyzed THRβ mRNA expression in surgical specimens from a series of human papillary ...
Celano, M +10 more
core +1 more source
Expression of sodium-iodide symporter in thyroid gland tumors: immunohistochemical study [PDF]
Морфологія, 2009 One of the key moments of radioiodine therapy, and also radioisotope diagnostics of cancers of a thyroid gland is ability of their cells to accumulate iodide.
Bondarenko O.O. +2 more
doaj
Sodium iodide symporter (NIS) in extrathyroidal malignancies: Focus on breast and urological cancer [PDF]
, 2014 BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia ...
BIANCHI, Giampaolo +8 more
core +1 more source