Results 51 to 60 of about 5,274 (210)

Reporter gene-engineering of human induced pluripotent stem cells during differentiation renders in vivo traceable hepatocyte-like cells accessible

Stem Cell Research, 2019
Primary hepatocyte transplantation (HTx) is a safe cell therapy for patients with liver disease, but wider application is circumvented by poor cell engraftment due to limitations in hepatocyte quality and transplantation strategies. Hepatocyte-like cells
Candice Ashmore-Harris, Samuel JI Blackford, Benjamin Grimsdell, Ewelina Kurtys, Marlies C Glatz, Tamir S Rashid, Gilbert O Fruhwirth   +6 more
doaj  

Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

BMC Cancer, 2012
Background Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects ...
Hutzen Brian, Pierson Christopher R, Russell Stephen J, Galanis Evanthia, Raffel Corey, Studebaker Adam W   +5 more
doaj   +1 more source

Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration

GeoHealth, Volume 9, Issue 2, February 2025.
Abstract The challenges of human space exploration produce some of humanity's greatest technological and scientific advances, not excluding innovations in medicine. The microgravity environment causes a host of physiological changes, and exposure to dust on the Moon caused considerable pulmonary distress to astronauts during the Apollo missions. As the
Justin L. Wang, Jeremy J. Rosenbaum, Ajay N. Prasad, Robert R. Raad, Esther J. Putman, Andrea D. Harrington, Haig Aintablian, Brian M. Hynek   +7 more
wiley   +1 more source

Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake. [PDF]

PLoS ONE, 2015
Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. The function of this membrane protein is closely regulated by post-translational glycosylation.
Taemoon Chung, Hyewon Youn, Chan Joo Yeom, Keon Wook Kang, June-Key Chung   +4 more
doaj   +1 more source

Breastfeeding and contrast agents—A critical review and presentation of new aspects

Fundamental &Clinical Pharmacology, Volume 39, Issue 1, February 2025.
Abstract Background There are discrepancies between guidelines of scientific societies and information of the package inserts of contrast media concerning breastfeeding following the application of a contrast agent to the mother. Objectives The contents of different review articles reflect the opinion of scientific societies.
Sina Lemmenmeier, Ingrid Boehm
wiley   +1 more source

Wild-Type P53 Induces Sodium/Iodide Symporter Expression Allowing Radioiodide Therapy in Anaplastic Thyroid Cancer

Cellular Physiology and Biochemistry, 2017
Aims: Anaplastic thyroid cancer(ATC) is one of the most aggressive solid tumors. Mutations in the p53 gene are common in anaplastic thyroid cancer, but the effects of p53 mutations are yet to be elucidated.
Lin Liu, Dan Li, Zhengqi Chen, Jian Yang, Yushui Ma, Haidong Cai, Chengxiang Shan, Zhongwei Lv, Xiaoping Zhang   +8 more
doaj   +1 more source

Differentiated thyroid cancer: Growth factors, oncogenes and environmental influences [PDF]

Archive of Oncology, 2003
The present data of growth factors, oncogenes, tumor-suppressor-genes and environmental factors can be summarized in thus: thyrotropin, growth factors and other hormones do increase thyrocyte growth and specific mutations of growth factor receptors ...
Paunović Ivan R.
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance cyprodinil

EFSA Journal, Volume 23, Issue 2, February 2025.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State France and co‐rapporteur Member State Bulgaria for the pesticide active substance cyprodinil are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Monica Fittipaldi Broussarad, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Alexandra Piti, Simone Rizzuto, Anamarija Romac, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +53 more
wiley   +1 more source

Comparison of and as Reporter Genes for Noninvasive Imaging of Bone Mesenchymal Stem Cells Transplanted into Infarcted Rat Myocardium

Molecular Imaging, 2011
The purpose of this study was to investigate and compare the feasibility of rat sodium iodide symporter ( rNIS ) and human sodium iodide symporter ( hNIS ) as reporter genes for noninvasive monitoring of rat bone marrow mesenchymal stem cells (rBMSCs ...
Shuo Hu, Wei Cao, Xiaoli Lan, Yong He, Juntao Lang, Congjiao Li, Jia Hu, Rei An, Zairong Gao, Yongxue Zhang   +9 more
doaj   +1 more source

Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter

EJNMMI Research, 2017
Background Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the new radiotracer (18F-TFB) for ...
Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee, Shin Young Jeong   +7 more
doaj   +1 more source