S-nitrosylation of NF-kB p65 inhibits TSH-induced Na+/I- symporter expression [PDF]
, 2015 Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces thyrotropin (TSH)-stimulated thyroid specific gene expression ...
Bocco, Jose Luis +8 more
core +3 more sources
Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology [PDF]
Endocrinology and Metabolism, 2014 Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of
June-Key Chung, Gi Jeong Cheon
doaj +1 more source
Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression [PDF]
, 2015 Purpose Down-regulation of thyroid hormone receptor beta (THRβ) gene has been described in several human malignancies, including thyroid cancer. In this study, we analyzed THRβ mRNA expression in surgical specimens from a series of human papillary ...
Celano, M +10 more
core +1 more source
International Journal of Endocrinology, 2018 Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao +7 more
doaj +1 more source
Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
core +1 more source
Expression of sodium-iodide symporter in thyroid gland tumors: immunohistochemical study [PDF]
Морфологія, 2009 One of the key moments of radioiodine therapy, and also radioisotope diagnostics of cancers of a thyroid gland is ability of their cells to accumulate iodide.
Bondarenko O.O. +2 more
doaj
Sodium iodide symporter (NIS) in extrathyroidal malignancies: Focus on breast and urological cancer [PDF]
, 2014 BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia ...
BIANCHI, Giampaolo +8 more
core +1 more source
Measles virus causes immunogenic cell death in human melanoma [PDF]
, 2011 Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn +14 more
core +1 more source
Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid
World Journal of Nuclear Medicine, 2012 Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana +3 more
doaj +1 more source
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Nature Communications, 2018 Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri +7 more
doaj +1 more source