Results 61 to 70 of about 22,963 (277)

Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells [PDF]

, 2016
n this study we analyzed the expression levels of markers of epithelial-to-mesenchymal transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor genotypes and clinicopathological characteristics.
Bulotta, Stefania, Celano, Marilena, Damante, Giuseppe, De Rose, Roberta Francesca, DURANTE, COSIMO, FILETTI, SEBASTIANO, Lombardo, Giovanni Enrico, Maggisano, Valentina, PECCE, VALERIA, ROSIGNOLO, FRANCESCA, Russo, Diego, SPONZIELLO, Marialuisa   +11 more
core   +1 more source

Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland [PDF]

Thyroid, 2013
Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia. NIS expression at
Adam Bobbey, Nathan Hall, Rebecca Nagy, Amy Lehman, Paul E. Wakely, Sissy M. Jhiang, Krista M. D. La Perle, David Jarjoura, Daniel H. Shen, Dong Chul Kim   +9 more
openaire   +3 more sources

HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]

, 2014
Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D, Li, H, Nace, R A, Nakashima, H, Russell, S J   +4 more
core   +1 more source

Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

PLoS ONE, 2020
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. NIS also transports other monovalent anions such as tetrafluoroborate (BF4-), pertechnetate (TcO4-), and thiocyanate (SCN-), and is competitively ...
S. Concilio, Hristina R. Zhekova, S. Noskov, S. Russell   +3 more
semanticscholar   +1 more source

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells [PDF]

, 2015
The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood.
ALVARO, Domenico, CARDINALE, VINCENZO, Carpino, Guido, Carrasco, Nancy, Dinh, Timothy A., GAUDIO, EUGENIO, Klimstra, David, Levine, Ronald, Oikawa, Tsunekazu, Reid, Lola M., Reyna Neyra, Andrea, Selitsky, Sara R., Sethupathy, Praveen, Wauthier, Eliane   +13 more
core   +2 more sources

Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Frontiers in Oncology, 2020
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which ...
H. Shang, Jun-yu Zhao, Jin-ming Yao, Huanjun Wang, Jianjun Dong, L. Liao   +5 more
semanticscholar   +1 more source

Effect of Mutations on Transport by the Sodium/Iodide Symporter (NIS) [PDF]

Biophysical Journal, 2015
The Na+/I- symporter (NIS) mediates iodide transport into the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. To understand the observed effects of single amino acid substitutions in the mechanism of transport by NIS, wild type NIS and NIS mutated at selected positions were studied using computational
L. Mario Amzel, Yuly E. Sánchez, Yuly E. Sánchez, Juan Pablo Nicola, Giuseppe Ferrandino, Nancy Carrasco   +5 more
openaire   +2 more sources

Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails

Anais da Academia Brasileira de Ciências
The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO, ALBA C.M. SILVA, IRACEMA G. ARAUJO, VICTOR M. TUNHOLI, VINÍCIUS M. TUNHOLI-ALVES, ROSANE N. CASTRO, DENISE P. CARVALHO, JAIRO PINHEIRO, MICHELLE P. MARASSI   +8 more
doaj   +1 more source

Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.

European Journal of Endocrinology, 2020
Objective Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).
A. Eleftheriadou, S. Mehl, K. Renko, Rega H. Kasim, Jasmin Schaefer, W. Minich, L. Schomburg   +6 more
semanticscholar   +1 more source

Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma [PDF]

Nuclear Medicine and Molecular Imaging, 2010
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).
Ho-Young Lee, Joo Hyun Kang, Keon Wook Kang, Hyewon Youn, June-Key Chung   +4 more
openaire   +3 more sources