Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid
World Journal of Nuclear Medicine, 2012 Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana +3 more
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Measles virus causes immunogenic cell death in human melanoma [PDF]
, 2011 Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn +14 more
core +1 more source
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Nature Communications, 2018 Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri +7 more
doaj +1 more source
Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells [PDF]
, 2016 n this study we analyzed the expression levels of markers of epithelial-to-mesenchymal transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor genotypes and clinicopathological characteristics.
Bulotta, Stefania +11 more
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HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]
, 2014 Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D +4 more
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Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland [PDF]
Thyroid, 2013 Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia. NIS expression at
Adam Bobbey +9 more
openaire +3 more sources
Frontiers in Oncology, 2020 Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which ...
H. Shang +5 more
semanticscholar +1 more source
Effect of Mutations on Transport by the Sodium/Iodide Symporter (NIS) [PDF]
Biophysical Journal, 2015 The Na+/I- symporter (NIS) mediates iodide transport into the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. To understand the observed effects of single amino acid substitutions in the mechanism of transport by NIS, wild type NIS and NIS mutated at selected positions were studied using computational
L. Mario Amzel +5 more
openaire +2 more sources
Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails
Anais da Academia Brasileira de CiênciasThe objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO +8 more
doaj +1 more source
Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells [PDF]
, 2015 The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood.
ALVARO, Domenico +13 more
core +2 more sources