Results 71 to 80 of about 22,819 (283)

Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.

European Journal of Endocrinology, 2020
Objective Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).
A. Eleftheriadou, S. Mehl, K. Renko, Rega H. Kasim, Jasmin Schaefer, W. Minich, L. Schomburg   +6 more
semanticscholar   +1 more source

Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma [PDF]

Nuclear Medicine and Molecular Imaging, 2010
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).
Ho-Young Lee, Joo Hyun Kang, Keon Wook Kang, Hyewon Youn, June-Key Chung   +4 more
openaire   +3 more sources

Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Theranostics, 2020
Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS).
Mariella Tutter, C. Schug, Kathrin A Schmohl, Sarah Urnauer, Nathalie Schwenk, M. Petrini, W. Lokerse, C. Zach, S. Ziegler, P. Bartenstein, W. Weber, E. Wagner, L. Lindner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]

, 2013
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K., Haghpanah, V., Hatami, E., Heshmat, R., Jahangirrad, A., Keshtkar, A., Kia, A., Larijani, B., Nabizadeh, R., Rohani, D., Roshandel, G., Semnani, S., Tabaeizadeh, M.   +12 more
core   +1 more source

Relationship between PI3K Mutation and Sodium-Iodide Symporter in Anaplastic Thyroid Carcinoma [PDF]

, 2015
The sodium-iodide symporter is a transmembrane protein that has important role in radio-iodide therapy in various cancers such as anaplastic thyroid carcinoma.
Bozorg-Ghalati, Farzaneh, Hedayati, Mehdi   +1 more
core  

A Critical Overview of Common Foodborne Toxicants and Methods for Their Reliable Detection

Food Frontiers, EarlyView.
ABSTRACT Food is an essential commodity for human health. However, toxicants such as mycotoxins, heavy metals, acrylamide, and pesticides can be present in food either naturally or through processing, packaging, or some anthropogenic activities. A thorough review of carefully selected studies revealed that climate change and pandemics have led to an ...
Betty Bowe Acquah, John‐Lewis Zinia Zaukuu   +1 more
wiley   +1 more source

General Principles of Secondary Active Transporter Function [PDF]

, 2019
Transport of ions and small molecules across the cell membrane against electrochemical gradients is catalyzed by integral membrane proteins that use a source of free energy to drive the energetically uphill flux of the transported substrate. Secondary active transporters couple the spontaneous influx of a "driving" ion such as Na$^+$ or H$^+$ to the ...
arxiv   +1 more source

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Charles J. Link, Nick Vahanian, Erica Roberson, Tatiana Seregina, Robert C. Unfer, Wayne Daniels, Elena Mitrofanova, Prem Seth   +7 more
openaire   +3 more sources

A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]

, 2019
Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J., Domingues, Rita, Faria, Márcia, Félix, Daniela, Matos, Paulo, Silva, Ana L.   +5 more
core   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source