Results 71 to 80 of about 22,963 (277)

A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]

, 2019
Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J., Domingues, Rita, Faria, Márcia, Félix, Daniela, Matos, Paulo, Silva, Ana L.   +5 more
core   +1 more source

Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Theranostics, 2020
Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS).
Mariella Tutter, C. Schug, Kathrin A Schmohl, Sarah Urnauer, Nathalie Schwenk, M. Petrini, W. Lokerse, C. Zach, S. Ziegler, P. Bartenstein, W. Weber, E. Wagner, L. Lindner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Charles J. Link, Nick Vahanian, Erica Roberson, Tatiana Seregina, Robert C. Unfer, Wayne Daniels, Elena Mitrofanova, Prem Seth   +7 more
openaire   +3 more sources

Relationship between PI3K Mutation and Sodium-Iodide Symporter in Anaplastic Thyroid Carcinoma [PDF]

, 2015
The sodium-iodide symporter is a transmembrane protein that has important role in radio-iodide therapy in various cancers such as anaplastic thyroid carcinoma.
Bozorg-Ghalati, Farzaneh, Hedayati, Mehdi   +1 more
core  

Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]

, 2013
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K., Haghpanah, V., Hatami, E., Heshmat, R., Jahangirrad, A., Keshtkar, A., Kia, A., Larijani, B., Nabizadeh, R., Rohani, D., Roshandel, G., Semnani, S., Tabaeizadeh, M.   +12 more
core   +1 more source

Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells

Journal of the Chinese Medical Association, 2020
Background: Thyroid tumors are the most frequent neoplasm of the endocrine system. The major treatment is surgical intervention followed by radioiodine therapy.
Jui-Yu Chen, Jane-Jen Wang, Hsin-Chen Lee, C. Chi, Chen-hsen Lee, Yi-Chiung Hsu   +5 more
semanticscholar   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Construction of a Fluorescence‐Based Logic Gate Seeing the Effect of Perchlorate Ions on Hemicyanine Dye–β‐Cyclodextrin Complexes to Certify Safe Drinking Water

ChemistryOpen, EarlyView.
A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M., Shalini Dyagala, Sairathna Choppella, Mahesh Kumar Ravva, Subit Kumar Saha   +4 more
wiley   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Anren Kuang, Da Mu, Rui Huang, Suping Li, Xiaojuan Ma   +4 more
core   +1 more source

Lacrimal duct obstruction after radioiodine therapy: case report and treatment [PDF]

, 2014
Iodotherapy represents the radioactive iodine therapy. The beta radiation emitted by radioactive iodine are particles that will be stored in the thyroid tissue destroying cancer cells that were left after surgery (thyroidectomy).
Lorena, Silvia Helena Tavares, Silva, João Amaro Ferrari   +1 more
core   +3 more sources