Results 81 to 90 of about 22,963 (277)

Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential

The Journal of Pathology, Volume 266, Issue 4-5, Page 405-420, August 2025.
Abstract Lung cancer is the leading cause of cancer‐related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein‐injected tumour cell lines or genetically modified mice. The current gold‐standard models typically present with multiple lung foci.
Ana‐Rita Pedrosa, Alejandro Castillo‐Kauil, Yuliia Kravchuk, Louise Reynolds, Bruce Williams, David Moore, Cameron Lang, Srinivas Allanki, Eleni Maniati, Alexandros Hardas, Jozafina Haj, Rebecca Drake, Julie Cleaver, Julie Foster, Jana Kim, Ester Stern, Jane Sosabowski, Gilbert O. Fruhwirth, Erik Sahai, Ori Wald, Kairbaan Hodivala‐Dilke   +20 more
wiley   +1 more source

PTTG and PBF repress the human sodium iodide symporter [PDF]

Oncogene, 2007
The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most thyroid tumours exhibit reduced iodide uptake, although the mechanisms accounting for this remain poorly understood.
Kristien Boelaert, Margaret C. Eggo, T Kogai, Vicki Smith, Jayne A. Franklyn, John Watkinson, L Tannahill, AL Stratford, Christopher McCabe   +8 more
openaire   +3 more sources

Hubungan Ekspresi Sodium Iodide Symporter dengan Varian Histopatologi dan Stadium Papillary Thyroid Carcinoma

Majalah Kedokteran Andalas
Abstrak                                                               Tujuan:  Mengetahui hubungan ekspresi sodium iodide symporter dengan varian histopatologi dan stadium papillary thyroid carcinoma.
Rini Purnama Sari, yenita - yenita, Noza - Hilbertina, tofrizal - tofrizal, Daan - Khambri, Husna - Yetti   +5 more
doaj   +1 more source

Real-time imaging of myoblast transplantation using the human sodium iodide symporter

BioTechniques, 2005
The quantification of the graft success is a key element to evaluate the efficiency of cellular therapies for several pathologies such as Duchenne muscular dystrophy. This study describes an approach to evaluate the success of myoblast transplantation (i.
Manaf Bouchentouf, Basma F. Benabdallah, Marcel Dumont, Joel Rousseau, Luc Jobin, Jacques P. Tremblay   +5 more
doaj   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR‐448/DNMT1/NIS Axis

Cancer Science, Volume 116, Issue 8, Page 2113-2124, August 2025.
Our study reveals that hypoxia inhibitors ameliorate iodine uptake dysfunction in thyroid cancer by acting on the hsa_circ_0023990/miR‐448/DNMT1/NIS signaling pathway. ABSTRACT This research seeks to investigate how hypoxia inhibitors enhance iodine uptake in thyroid cancer cells. Clinical samples were gathered and assessed for hsa_circ_0023990, DNMT1,
Ruiqin Gou, Shiqi Chen, Yangyang Lei, Pengqing Wu, Xuezhong Chen, Qing Zhang   +5 more
wiley   +1 more source

Genomics‐assisted breeding for designing salinity‐smart future crops

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3119-3151, August 2025.
This review explores fast‐forward genomics‐assisted breeding tools to fast‐track the designing of salinity‐smart crops. Integration of various breeding tools can enhance salinity tolerance, ensuring sustainable agriculture and global food security. Summary Climate change induces many abiotic stresses, including soil salinity, significantly challenging ...
Ali Raza, Qamar U. Zaman, Sergey Shabala, Mark Tester, Rana Munns, Zhangli Hu, Rajeev K. Varshney   +6 more
wiley   +1 more source

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Cellular Physiology and Biochemistry, 2014
Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J. Rhoden   +10 more
doaj   +1 more source

Anti-thyroid antibodies: methodological aspects and diagnostic significance [PDF]

, 2003
Since the first publication, more than 40 years ago, laboratory tests for the presence of antibodies (Ab) to thyroid antigens (Ag) have played a pivotal position in the diagnosis of thyroid diseases.
Hauache, Omar M., Kasamatsu, Teresa S., Maciel, Rui Monteiro de Barros, Vieira, José Gilberto H.   +3 more
core   +3 more sources

Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity, inflammation, and oxidative stress to thyroid cancer.
Bo‐Tao Zhang, Mao Guo, Liu‐Rui Yang, Yang Zeng, Jun Jiang   +4 more
wiley   +1 more source