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Characterization of the upstream enhancer of the rat sodium/iodide symporter gene
Experimental and Clinical Endocrinology & Diabetes, 2001We previously demonstrated the presence of an enhancer that is located between nucleotides - 2264 and - 2495 in the 5' flanking region of the rat sodium/iodide symporter (NIS) gene (Ohno et al., 1999). When attached to NIS or heterologous promoters, this 232 bp fragment, which we call NUE, is able to stimulate transcription in a thyroid-specific and ...
CHUN J. T., DI LAURO, ROBERTO
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Sodium Iodide Symporter in the Fight Against Thyroid Cancer
Future Oncology, 2013n radioiodide n signal transduction inhibitor n sodium iodide symporter n thyroid cancer More than 60 years of experience of radioiodide therapy has indicated its usefulness for the treatment of differentiated thyroid cancer. This therapy utilizes the differentiated function of thyroid cells, namely iodide uptake for thyroid hormone synthesis.
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Sodium Iodide Symporter in Thyroid Carcinoma
2012Thyroid iodide uptake is essential for the clinical application of radioiodine in patients with well-differentiated thyroid carcinoma. Iodide uptake occurs across the plasma membranes of thyroid follicular cells and cancer cells via an active transporter process mediated by sodium iodide symporter (NIS).
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Visualisation of sodium-iodide symporter
European Journal of Nuclear Medicine and Molecular Imaging, 2005Montserrat, Estorch +6 more
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The sodium iodide symporter and thyroid disease
Clinical Endocrinology, 2002Peter P A, Smyth, Roisin M, Dwyer
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[The practical relevance of the sodium iodide symporter].
Zeitschrift fur arztliche Fortbildung und Qualitatssicherung, 2004The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein mediating the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular in the lactating mammary gland. Because of its crucial role for the ability of thyroid follicular cells to trap iodide, cloning of NIS opened up an exciting and ...
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Regulation of Sodium/Iodide Symporter
Reviews in Endocrine and Metabolic Disorders, 2000openaire +2 more sources
Prokaryotic Solute/Sodium Symporters: Versatile Functions and Mechanisms of a Transporter Family
International Journal of Molecular Sciences, 2021Dan Su, Larissa Wirtz, Heinrich Jung
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