Results 101 to 110 of about 16,105 (218)

Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling

, 2014
The Na(+)-coupled betaine symporter BetP shares a highly conserved fold with other sequence unrelated secondary transporters, for example, with neurotransmitter symporters. Recently, we obtained atomic structures of BetP in distinct conformational states,
Ziegler, Christine, Faust, Belinda, Mehdipour, Ahmadreza, Francesconi, Kevin A., Francesconi, K., Faust, B., Mehdipour, A., Perez, Camilo, Ziegler, C., Mehdipour, Ahmad Reza, Perez, C., Forrest, L., Forrest, Lucy R.   +12 more
core   +1 more source

The SLC6/NSS family members KAAT1 and CAATCH1 have weak chloride dependence

, 2008
KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta.(1,2) They are members of the SLC6/NSS family, which groups membrane proteins that use Na+, K+ and Cl- gradients for the coupled transport of amines ...
S. Bettè, E. Bossi, M. Castagna, A. Peres, V.F. Sacchi   +4 more
core   +1 more source

Investigations on the regulation of the sodium iodide symporter (NIS) and the thyroperoxidase (TPO) by sterol regulatory element-binding proteins (SREBPs)

, 2014
Eine Dysfunktion des Natrium-Iodid-Symporters (NIS) oder der Thyreoperoxidase (TPO) führen zu einer beeinträchtigten Synthese der Schilddrüsenhormone, aus der das klinische Bild der Hypothyreose hervorgeht.
Rauer, Christine
core   +1 more source

The BCCT family of carriers: from physiology to crystal structure

, 2010
Increases in the environmental osmolarity are key determinants for the growth of microorganisms. To ensure a physiologically acceptable level of cellular hydration and turgor at high osmolarity, many bacteria accumulate compatible solutes.
Bremer, Erhard, Ziegler, C., Reinhard Krämer, Christine Ziegler, Bremer, E., Krämer, R., Erhard Bremer, Krämer, Reinhard, Ziegler, Christine Maria   +8 more
core   +1 more source

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.

Endocrine-Related Cancer, 2021
C. Spitzweg, P. Nelson, E. Wagner, P. Bartenstein, W. Weber, M. Schwaiger, J. Morris, Christopher McCabe   +7 more
semanticscholar   +1 more source

Identification of antigenic domains on the human sodium‐iodide symporter which are recognized by autoantibodies from patients with autoimmune thyroid disease

Clinical and Experimental Immunology, 2001
E. Kemp, E. Waterman, R. Ajjan, K. A. Smith, P. Watson, M. Ludgate, A. Weetman   +6 more
semanticscholar   +1 more source

A New Theranostic Paradigm for Advanced Thyroid Cancer

Journal of Nuclear Medicine, 2016
D. Pattison, B. Solomon, R. Hicks
semanticscholar   +1 more source

Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition

Archives of Toxicology, 2021
Jun Wang, A. Richard, A. Murr, A. Buckalew, Ryan R. Lougee, Mahmoud Shobair, D. Hallinger, S. Laws, T. Stoker   +8 more
semanticscholar   +1 more source

Untersuchungen zur Bedeutung der sterol regulatory element-binding proteins in der Regulation des Natrium-Iodid-Symporters in Milchdrüsenzellen

, 2015
Der Natrium-Iodid-Symporter (NIS) ist ein wichtiges Protein im Iod-Haushalt der Säugetiere. Er ist notwendig für die Aufnahme von Iodid über den Darm in die Blutbahn und somit für die Versorgung des Organismus mit diesem essentiellen Spurenelement. Da es
Pachner, Leila Isabel
core   +1 more source

Conformational Dynamics of Neurotransmitter:Sodium Symporters: Insights from MhsT and hSERT

Neurotransmitter:sodium symporters (NSSs) play critical roles in neural signaling by regulating neurotransmitter uptake into cells powered by sodium electrochemical gradients.
Schwartz, Alexandra Corinne
core