Results 81 to 90 of about 823 (135)

Adaptive evolution of <i>Pseudomonas putida</i> in the presence of fluoride exposes novel functions of a benzoate transporter. [PDF]

J Bacteriol
Ets L, Ilves H, Juhe L, Ilmjärv T, Puiggené Ò, Nikel PI, Kivisaar M.   +6 more
europepmc   +1 more source

Ingested nitrate and nitrite, drinking water disinfection by-products, and incidence of thyroid cancer among licensed pesticide applicators and spouses in the Agricultural Health Study. [PDF]

Ecotoxicol Environ Saf
Chen D, Parks CG, Beane Freeman LE, Hofmann JN, Spaur M, Madrigal JM, Sinha R, Jones RR, Ward MH, Sandler DP.   +9 more
europepmc   +1 more source

Structural insights into the mechanism of the sodium/iodide symporter

Yearbook of Paediatric Endocrinology, 2022
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I-) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones-the master regulators of intermediary metabolism. NIS couples the inward translocation of I- against its electrochemical gradient to the inward transport
Silvia Ravera, Juan Pablo Nicola, Glicella Salazar-De Simone, Fred J. Sigworth, Erkan Karakas, L. Mario Amzel, Mario A. Bianchet, Nancy Carrasco   +7 more
openaire   +2 more sources

Cloning of the Mouse Sodium Iodide Symporter

Thyroid, 2001
The iodide-concentrating ability of the thyroid gland is essential to the production of thyroid hormone. We report the nucleotide and amino acid sequence of the mouse sodium iodide symporter (mNIS), which mediates this activity within the thyroid gland.
L A, Pinke, D S, Dean, E R, Bergert, C, Spitzweg, C M, Dutton, J C, Morris   +5 more
openaire   +2 more sources

Sodium Iodide Symporter in Health and Disease

Thyroid, 2001
Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy.
D H, Shen, R T, Kloos, E L, Mazzaferri, S M, Jhian   +3 more
openaire   +2 more sources

The Sodium-Iodide Symporter

Current Drug Targets Immune, Endocrine and Metabolic Disorders, 2004
The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
C H, Baker, J C, Morris
exaly   +3 more sources

Sodium/iodide symporter in thyroid cancer

Experimental and Clinical Endocrinology & Diabetes, 2001
[No abstract available]
C. Mian, L. Lacroix, J. M. Bidart, B. Caillou, FILETTI, SEBASTIANO, M. Schlumberger   +5 more
openaire   +4 more sources

Approaches to gene therapy with sodium/iodide symporter

Experimental and Clinical Endocrinology & Diabetes, 2001
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy.
C, Spitzweg, J C, Morris
openaire   +2 more sources

Expression of the Sodium/Iodide Symporter in Human Prostate Adenocarcinoma

Urology, 2010
To analyze expression of the sodium/iodide symporter (NIS) in tissue specimen from a large series of patients with prostate adenocarcinoma. Few data are available on the NIS expression in prostate tumor tissues.NIS protein expression was examined by immunohistochemistry in 78 tumor tissue specimen and their non-neoplastic counterparts.
M. Navarra, MICALI, Salvatore, SM lepore, AM Cesinaro, M. Celano, MC Sighinolfi, C. De Gaetani, S. Filetti, BIANCHI, Giampaolo, D. Russo   +9 more
openaire   +3 more sources