Results 81 to 90 of about 16,105 (218)

Haloarchaeal osmoadaptation.

, 2014
(A) Generalized model for osmoadaptation in the haloarchaea. During osmotic upshock, potassium is imported through Trk H+/K+ symporters and Na+ is expelled using a combination of NhaC H+/Na+ antiporters and/or YrbG Ca2+/Na+ antiporters.
Dominique Madern (659600), Jonathan A. Eisen (93505), Marc T. Facciotti (135485), David Larsen (659597), Erin A. Becker (488025), Megan Krusor (659598), Phillip M. Seitzer (100543), Andrew I. Yao (659599), Dongying Wu (9076), Aaron E. Darling (51840), Andrew Tritt (135481)   +10 more
core   +1 more source

Neurochemical Research / The amino terminus of LeuT changes conformation in an environment sensitive manner

, 2020
Neurotransmitter:sodium symporters are highly expressed in the human brain and catalyze the uptake of substrate through the plasma membrane by using the electrochemical gradient of sodium as the energy source.
Jayaraman, Kumaresan, Sohail, Azmat, Sandtner, Walter, Szöllősi, Dániel, Khan, Jawad A., Stockner, Thomas, Sitte, Harald H.   +6 more
core   +1 more source

Enhancement of 211At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer

Journal of Nuclear Medicine, 2019
211At is an α-emitter that has similar chemical properties to iodine and is used in targeted α-therapy. In the present study, we added ascorbic acid (AA) to 211At solution to increase the radiochemical purity of astatide and evaluated its efficacy ...
T. Watabe, K. Kaneda-Nakashima, Yuwei Liu, Y. Shirakami, K. Ooe, A. Toyoshima, E. Shimosegawa, M. Fukuda, A. Shinohara, J. Hatazawa   +9 more
semanticscholar   +1 more source

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes

Stem Cells Translational Medicine, 2020
Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell‐based cardiac therapies.
John W Ostrominski, R. Yada, N. Sato, M. Klein, K. Blinova, Dakshesh Patel, Racquel R. Valadez, M. Palisoc, S. Pittaluga, K. Peng, H. San, Yongshun Lin, F. Basuli, Xiang Zhang, R. Swenson, M. Haigney, P. Choyke, J. Zou, M. Boehm, S. Hong, C. Dunbar   +20 more
semanticscholar   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Fluoride Exposure Induces Inhibition of Sodium/Iodide Symporter (NIS) Contributing to Impaired Iodine Absorption and Iodine Deficiency: Molecular Mechanisms of Inhibition and Implications for Public Health

International Journal of Environmental Research and Public Health, 2019
The sodium iodide symporter (NIS) is the plasma membrane glycoprotein that mediates active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa, rectal mucosa, bronchial mucosa, placenta and mammary glands.
Declan T Waugh
semanticscholar   +1 more source

Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS)

Journal of Chemical Information and Modeling, 2020
The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid ...
Hristina R. Zhekova, Toshie Sakuma, Ryan Johnson, S. Concilio, P. Lech, I. Zdravkovic, Mirna Damergi, L. Suksanpaisan, K. Peng, S. Russell, S. Noskov   +10 more
semanticscholar   +1 more source

High‐Loaded Bismuth Oxide/Copper Silicone Rubber Composites and Their Application as Shielding Collar for I‐131 Treated Thyroid Cancer Patients

SPE Polymers, Volume 7, Issue 1, January 2026.
Development of high‐filler‐content silicone rubber composites containing up to 80 wt% bismuth oxide or copper, demonstrating significant I‐131 attenuation with retained flexibility and durability. ABSTRACT The development of flexible, non‐lead radiation‐shielding materials remains a critical challenge, particularly for I‐131 protection, where no ...
Kanaungnit Kingpetch, Supatporn Tepmongkol, Anchali Krisanachinda, Piyachai Khomein   +3 more
wiley   +1 more source

Activation of the sodium pump blocks the growth hormone-induced increase in cytosolic free calcium in rat adipocytes

, 2008
GH promptly increases cytosolic free calcium ([Ca2+]i) in freshly isolated rat adipocytes. Adipocytes deprived of GH for 3 h or longer are incapable of increasing [Ca2+]i in response to GH, but instead respond in an insulin-like manner.
Gaur, Shikha, Yamaguchi, Hiroshi, Goodman, H. Maurice   +2 more
core   +1 more source

Bidirectional ion transport in thyroid: Secretion of anions by monolayer cultures that absorb sodium

, 1992
Cultured porcine thyroid cell monolayers transport Na in an apical-to-basal direction, resulting in the development of a basal-positive transepithelial potential difference (TEP) and the formation of domes (fluid-filled elevations of the cell layer above
Manley S.W., Cragoe Jr. E.J., Huxham G.J., Bourke J.R., Armstrong J., Matainaho T.   +5 more
core   +2 more sources