Results 61 to 70 of about 16,105 (218)

Biology of Human Sodium Glucose Transporters

, 2011
There are two classes of glucose transporters involved in glucose homeostasis in the body, the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters (SGLTs).
Ernest M. Wright, Bruce A. Hirayama, Donald D. F. Loo   +2 more
core   +1 more source

Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. [PDF]

, 2018
Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes.
Grabe, Michael, Jacobson, Matthew P, Polizzi, Nicholas F, Althoff, Thorsten, Bisignano, Paola, Jo, Hyunil, Ghezzi, Chiara, Wright, Ernest M, Friemann, Rosmarie,, Friemann, Rosmarie, Kalyanaraman, Chakrapani   +10 more
core   +1 more source

TG Nonsense Variant in Dwarf Rottweiler Dogs

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT We identified a dwarfism syndrome in six Rottweiler dogs characterized by reduced height and body weight; limb deformities, shortening of the tail and abnormally thick skin in puppies; developmental delays, pain and non‐goitrous hypothyroidism. Histological examination of the thyroid gland revealed severe chronic diffuse bilateral atrophy with
Marie Abitbol, Michaela Drögemüller, Cleo Schwarz, Etienne Furthner, Eva Dervas, Felicitas S. Boretti, Nadja S. Sieber‐Ruckstuhl, Caroline Dufaure de Citres, Chloé Pauchard, Vidhya Jagannathan, Tosso Leeb   +10 more
wiley   +1 more source

Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

PLoS ONE, 2020
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. NIS also transports other monovalent anions such as tetrafluoroborate (BF4-), pertechnetate (TcO4-), and thiocyanate (SCN-), and is competitively ...
S. Concilio, Hristina R. Zhekova, S. Noskov, S. Russell   +3 more
semanticscholar   +1 more source

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR [PDF]

, 2017
The Neurotransmitter:Sodium Symporters (NSSs) represent an important class of proteins mediating sodium-dependent uptake of neurotransmitters from the extracellular space.
Larsen, Flemming Hofmann, Teilum, Kaare, Loland, Claus J, Oschkinat, Hartmut, Barth-Jan van Rossum, van Rossum, Barth-Jan, Gotfryd, Kamil, Hartmut Oschkinat, Kamil Gotfryd, Michel-Andreas Geiger, Mortensen, Jonas Sigurd, Ulrik Gether, Flemming Hofmann Larsen, Jonas Sigurd Mortensen, Kaare Teilum, Geiger, Michel-Andreas, Simon Erlendsson, Løland, Claus Juul, Gether, Ulrik, Erlendsson, Simon, Claus J Loland   +20 more
core   +1 more source

Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells

Journal of the Chinese Medical Association, 2020
Background: Thyroid tumors are the most frequent neoplasm of the endocrine system. The major treatment is surgical intervention followed by radioiodine therapy.
Jui-Yu Chen, Jane-Jen Wang, Hsin-Chen Lee, C. Chi, Chen-hsen Lee, Yi-Chiung Hsu   +5 more
semanticscholar   +1 more source

Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Frontiers in Oncology, 2020
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which ...
H. Shang, Jun-yu Zhao, Jin-ming Yao, Huanjun Wang, Jianjun Dong, L. Liao   +5 more
semanticscholar   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells

PLoS ONE, 2020
The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI ...
Márcia Faria, Rita Domingues, F. Paixao, Maria João M Bugalho, P. Matos, Ana Luísa Silva   +5 more
semanticscholar   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source