Results 51 to 60 of about 16,105 (218)

Uniport, Not Proton-Symport, in a Non-Mammalian SLC23 Transporter.

, 2022
SLC23 family members are transporters of either nucleobases or ascorbate. While the mammalian SLC23 ascorbate transporters are sodium-coupled, the non-mammalian nucleobase transporters have been proposed, but not formally shown, to be proton-coupled ...
Holzhüter, K., Geertsma, E.
core   +1 more source

The sodium iodide symporter: its pathophysiological and therapeutic implications [PDF]

Clinical Endocrinology, 2002
SummaryThe sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and ...
Christine, Spitzweg, John C, Morris
openaire   +2 more sources

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma [PDF]

Nuclear Medicine and Molecular Imaging, 2010
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).
June-Key, Chung, Hye Won, Youn, Joo Hyun, Kang, Ho Young, Lee, Keon Wook, Kang   +4 more
openaire   +2 more sources

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionuclide Therapy for Glioblastoma

Cancers
Simple Summary Glioblastoma (GBM) is the most common glioma, which belongs to the aggressive and malignant type of brain tumor. Conventional treatments such as surgical resection, adjuvant radiotherapy, and concomitant and adjuvant temozolomide ...
Siddharth Shah, Brandon P. Lucke-Wold
semanticscholar   +1 more source

Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland [PDF]

Thyroid, 2013
Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia. NIS expression at
Krista M D, La Perle, Dong Chul, Kim, Nathan C, Hall, Adam, Bobbey, Daniel H, Shen, Rebecca S, Nagy, Paul E, Wakely, Amy, Lehman, David, Jarjoura, Sissy M, Jhiang   +9 more
openaire   +2 more sources

Endogenous RALF peptide function is required for powdery mildew host colonization

New Phytologist, EarlyView.
Model of RALF‐FER‐dependent effects on powdery mildew sporulation. Summary The receptor kinase FERONIA (FER) is a susceptibility factor for biotrophic powdery mildew fungal pathogens in Arabidopsis thaliana, but the underlying molecular mechanisms remain largely unknown. FER is required for the perception of endogenous RAPID ALKALINIZATION FACTOR (RALF)
Henriette Leicher, Sebastian D. Schade, Jan W. Huebbers, Kristina S. Munzert‐Eberlein, Genc Haljiti, David Biermann, Athanasios Makris, Xiaoxuan Zhu, Yashank Chauhan, Christina Ludwig, Marion C. Müller, Toshinori Kinoshita, Timo Engelsdorf, Julien Gronnier, Martina K. Ried‐Lasi, Aurélien Boisson‐Dernier, Ralph Hückelhoven, Martin Stegmann   +17 more
wiley   +1 more source

Additional file 3 of Seasonal patterns in microbial carbon and iron transporter expression in the Southern Ocean

, 2023
Additional file 3: Supplementary Figure 3. Relative proportions of transporter families. Bar-plot showing the relative proportions of different transporter families according to the transporter database (TBDB) for A.
Ying Sun (16853148), Pavla Debeljak (16853142), Barbara Bayer (16853145), Gerhard J. Herndl (10785096), Ingrid Obernosterer (16853151)   +4 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source