Results 41 to 50 of about 16,105 (218)

The major amino acid transporter superfamily has a similar core structure as Na+-galactose and Na+-leucine transporters [PDF]

, 2008
The sodium solute symporters (SSS) and neurotransmitter sodium symporters (NSS) are two families of secondary transporters that are not related in amino acid sequence.
Lolkema, Juke S.,, Slotboom, Dirk-Jan,, Lolkema, Juke S., Slotboom, Dirk-Jan   +3 more
core   +1 more source

Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter

, 2022
In search for novel antibacterial compounds, bacterial sialic acid uptake inhibition represents a promising strategy. Sialic acid plays a critical role for growth and colonisation of several pathogenic bacteria, and its uptake inhibition in bacteria was ...
Bozzola, Tiago, Nilsson, Ulf J.,, Ellervik, Ulf,, Ellervik, Ulf, Richard E. Johnsson, Johnsson, Richard E.,, Nilsson, Ulf J., Bozzola, Tiago,, Johnsson, Richard E., Ulf J. Nilsson, Lund University., Tiago Bozzola, Ulf Ellervik   +12 more
core   +1 more source

Characterization of small-molecule inhibitors of the sodium iodide symporter [PDF]

Journal of Endocrinology, 2008
The sodium/iodide symporter (NIS) mediates the active transport of iodide from the bloodstream into thyrocytes. NIS function is strategic for the diagnosis and treatment of various thyroid diseases. In addition, a promising anti-cancer strategy based on targeted NIS gene transfer in non-thyroidal cells is currently developed.
Lindenthal, Sabine, Lecat-Guillet, Nathalie, Ambroise, Yves, Rousseau, Bernard, Pourcher, Thierry, Ondo Méndez, Alejandro Oyono   +5 more
openaire   +3 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1 [PDF]

, 2018
Na+-coupled acid–base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na+-coupled acid–base transporters are not available.
Kirill Tsirulnikov, Rustam Azimov, Huynh, Kevin W, Alexander Pushkin, K. Tsirulnikov, Jiang, Jiansen, J. Jiang, Kao, Liyo, Shao, Xuesi, Debra Newman, Z. Hong Zhou, R. Azimov, I. Kurtz, Pushkin, Alexander, Kurtz, Ira, D. Newman, Abuladze, Natalia, Jiansen Jiang, X. Shao, Tsirulnikov, Kirill, Liyo Kao, N. Abuladze, Newman, Debra, Xuesi Shao, Z.H. Zhou, Natalia Abuladze, L. Kao, A. Pushkin, Azimov, Rustam, Kevin W. Huynh, K.W. Huynh, Ira Kurtz, Zhou, Z Hong   +32 more
core   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

, 2014
Neurotransmitter sodium symporters NSSs terminate synaptic signal transmission by Na dependent reuptake of released neurotransmitters. Key conformational states have been reported for the bacterial homolog LeuT and an inhibitor bound Drosophila ...
Jonathan A Javitch, Reinhard, L., Quick, M., Javitch, J.A., Lina Malinauskaite, Joseph A Lyons, Yano, H., Malinauskaite, L., Linda Reinhard, Hideaki Yano, Nissen, P., Poul Nissen, Matthias Quick, Lyons, J.A.   +13 more
core   +1 more source

PTTG and PBF repress the human sodium iodide symporter [PDF]

Oncogene, 2007
The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most thyroid tumours exhibit reduced iodide uptake, although the mechanisms accounting for this remain poorly understood.
K, Boelaert, V E, Smith, A L, Stratford, T, Kogai, L A, Tannahill, J C, Watkinson, M C, Eggo, J A, Franklyn, C J, McCabe   +8 more
openaire   +2 more sources

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Transporter oligomerisation: roles in structure and function [PDF]

, 2018
Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features ...
Byrne, Bernadette, Cecchetti, Cristina, Pyle, Euan   +2 more
core   +1 more source