Results 41 to 50 of about 823 (135)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Homology of pendrin sodium-iodide symporter and apical iodide transporter

Frontiers in Bioscience, 2018
We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins.
Benvenga, Salvatore, Guarneri, Fabrizio
openaire   +3 more sources

Translational Research Using Sodium/Iodide Symporter

Journal of Korean Endocrine Society, 2006
184 1915년에 갑상선 조직에 요오드가 선택적으로 축적된다 는 사실이 밝혀졌고, 그 이후 갑상선 질환의 진단과 치료에 방사성요오드가 널리 이용되게 되었다. 갑상선 조직은 요오 드를 혈액에서부터 20~40배 정도 높은 농도로 축적한다. 약 60년 전부터 방사성요오드를 갑상선 기능을 측정하는 추적 자로 사용하였고, 곧이어 갑상선기능항진증과 갑상선암에서 I-131를 치료제로 사용하게 되었다. 그러나 갑상선 세포에 요오드가 선택적으로 섭취되는 기 전은 최근에야 밝혀졌다.
June-Key Chung, Joo Hyun Kang
openaire   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Homology Modelling of Sodium Iodide Symporter [PDF]

Biophysical Journal, 2018
Hristina R. Zhekova, Igor Zdravkovic, Sergei Yu Noskov, Toshie Sakuma, Susanna C. Concilio, Ryan Johnson, Stephen J. Russell, Kah-Whye Peng   +7 more
openaire   +1 more source

Assessing the sodium-iodide symporter (NIS) in pediatric differentiated thyroid carcinoma. [PDF]

Eur Thyroid J
Alves-Junior PAG, Araujo ML, Neto PN, Valverde P, Lima SCS, Pinto LFR, Cerutti JM, Vaisman F.   +7 more
europepmc   +1 more source

Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma. [PDF]

Cells, 2023
Garcia N, Ulin M, Yang Q, Ali M, Bosland MC, Zeng W, Chen L, Al-Hendy A.   +7 more
europepmc   +1 more source

Unilateral Graves disease with Takayasu arteritis. [PDF]

JCEM Case Rep
Hari Kumar KVS, Jariwala P, Guddeti A.
europepmc   +1 more source

Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements. [PDF]

Redox Biol
Psarias G, Ziros PG, Mageiropoulou A, Chartoumpekis DV, Habeos GI, Alomair BM, Duntas L, Trougakos IP, Sykiotis GP.   +8 more
europepmc   +1 more source