Results 21 to 30 of about 16,105 (218)

Evolution and developmental expression of the sodium–iodide symporter ( NIS , slc5a5) gene family: Implications for perchlorate toxicology

Evolutionary Applications, 2022
The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function
Ann M. Petersen, C. M. Small, Yi-Lin Yan, C. Wilson, P. Batzel, R. Bremiller, C. Buck, F. A. Hippel, W. Cresko, J. Postlethwait   +9 more
semanticscholar   +1 more source

Expression of the sodium iodide symporter in human kidney [PDF]

Kidney International, 2001
The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Spitzweg, Christine, Dutton, Charyl M., Castro, Maria R., Bergert, Elizabeth R., Goellner, John R., Heufelder, Armin E., Morris, John C.   +6 more
openaire   +2 more sources

Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells

Cancers, 2022
Simple Summary Most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis. However, a significant number progress to advanced disease exhibiting aggressive clinical characteristics.
Márcia Faria, José Vareda, Micaella Miranda, Maria João M Bugalho, Ana Luísa Silva, Paulo Matos   +5 more
semanticscholar   +1 more source

Dimerization of the Sodium/Iodide Symporter

Thyroid®, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson, Rebecca J., Fletcher, Alice, Brookes, Katie, Nieto, Hannah, Alshahrani, Mohammed M., Mueller, Jonathan W., Fine, Nicholas H.F., Hodson, David J., Boelaert, Kristien, Read, Martin L., Smith, Vicki E., McCabe, Christopher J.   +11 more
openaire   +2 more sources

Potassium Iodide Nanoparticles Enhance Radiotherapy against Breast Cancer by Exploiting the Sodium-Iodide Symporter

ACS Nano, 2021
Iodine has shown promise in enhancing radiotherapy. However, conventional iodine compounds show fast clearance and low retention inside cancer cells, limiting their application as a radiosensitizer.
Benjamin Cline, Wen Jiang, Chaebin Lee, Zhengwei Cao, Xueyuan Yang, Shuyue Zhan, Harrison Chong, Tao Zhang, Zhaoguo Han, Xuedan Wu, L. Yao, Hui Wang, Weizhong Zhang, Zibo Li, Jin Xie   +14 more
semanticscholar   +1 more source

Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]

Hormones and Cancer, 2014
Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Aparna, Lakshmanan, Daniel, Scarberry, Daniel H, Shen, Sissy M, Jhiang   +3 more
openaire   +2 more sources

Function Trumps Form in Two Sugar Symporters, LacY and vSGLT

, 2021
Active transport of sugars into bacteria occurs through symporters driven by ion gradients. LacY is the most well-studied proton sugar symporter, whereas vSGLT is the most characterized sodium sugar symporter.
Jeff Abramson, Ernest M. Wright
core   +1 more source

The molecular mechanism of secondary sodium symporters elucidated through the lens of the computational microscope [PDF]

, 2016
Transport of molecules across cellular membranes is a key biological process for normal cell function. As such, secondary active transporters exploit electrochemical ion gradients to carry out fundamental processes, i.e. nutrients uptake, ion regulation,
Bisha, Ina, Magistrato, Alessandra, Alessandra Magistrato, Ina Bisha   +3 more
core   +1 more source

The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation

OncoTargets and Therapy, 2021
Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
T. Anekpuritanang, Maythad Uataya, Apichaya Claimon, Natthawadee Laokulrath, Warut Pongsapich, Paveena Pithuksurachai   +5 more
semanticscholar   +1 more source

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. [PDF]

, 1994
Cell surface receptors for gibbon ape leukemia virus (Glvr-1) and murine amphotropic retrovirus (Ram-1) are distinct but related proteins having multiple membrane-spanning regions.
Kozak, Susan L., D. G. Miller, Kabat, David, W. Zhang, A. D. Miller, Zhang, Weibin, S. L. Kozak, M. P. Kavanaugh, D. Kabat, Law, Wendy, W. Law, Miller, Daniel G., Miller, A. Dusty, Kavanaugh, Michael   +13 more
core   +1 more source