Results 11 to 20 of about 16,105 (218)

Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.

Journal of Endocrinology, 2008
International audienceThe active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I- symporter (NIS). We studied mouse NIS (mNIS) and found that it catalyzes iodide transport into transfected cells more ...
M. Dayem, C. Basquin, V. Navarro, Patricia Carrier, R. Marsault, Patrick Chang, S. Huc, E. Darrouzet, S. Lindenthal, T. Pourcher   +9 more
semanticscholar   +2 more sources

Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment.

Biochimica et Biophysica Acta, 2011
The sodium/iodide symporter is an intrinsic membrane protein that actively transports iodide into thyroid follicular cells. It is a key element in thyroid hormone biosynthesis and in the radiotherapy of thyroid tumours and their metastases. Sodium/iodide
S. Huc-Brandt, Didier Marcellin, Fanny Graslin, Olivier Averseng, L. Bellanger, P. Hivin, E. Quéméneur, C. Basquin, V. Navarro, T. Pourcher, E. Darrouzet   +10 more
semanticscholar   +2 more sources

Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor. [PDF]

Birth Defects Res
ABSTRACT Background Fluoride has come under recent scrutiny regarding concerns over potential neurodevelopmental and endocrine‐related toxicities, with recent reviews by the National Toxicology Program (NTP) and European Food Safety Authority (EFSA) concluding with moderate or reasonable confidence, respectively, that exposure to drinking water having ...
Mudd AM, Ovando BJ, Daston GP.
europepmc   +2 more sources

Molecular Traces of Gastric Cancer in Saliva: From Tissue Signatures to Salivary SLC5A5 as a Potential Biomarker. [PDF]

United European Gastroenterol J
ABSTRACT Background Early detection of gastric cancer (GC) and reliable risk stratification for metachronous gastric lesions (MGLs) remain societal and clinical challenges, particularly in intermediate risk populations. Non‐invasive approaches such as saliva‐based biomarkers could complement current strategies. The aim of this study was to identify and
Lopes C, Brandão A, Vavoulis D, Paulino S, Costa J, de Sá IM, Archer S, Küttner-Magalhães R, Marcos-Pinto R, Libânio D, Dinis-Ribeiro M, Pereira C.   +11 more
europepmc   +2 more sources

Mesenchymal Stem Cell-mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice.

Clinical Cancer Research, 2022
PURPOSE Mesenchymal stem cells (MSCs) have emerged as cellular-based vehicles for the delivery of therapeutic genes in cancer therapy based on their inherent tumor homing capability.
Carolin Kitzberger, Rebekka Spellerberg, Yang Han, Kathrin A Schmohl, Christina Stauss, Christian Zach, R. Kälin, G. Multhoff, Mathias Eiber, F. Schilling, R. Glass, W. Weber, E. Wagner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy

EJNMMI Research, 2022
Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by ...
Carolin Kitzberger, Rebekka Spellerberg, V. Morath, Nathalie Schwenk, Kathrin A Schmohl, C. Schug, Sarah Urnauer, Mariella Tutter, M. Eiber, F. Schilling, W. Weber, S. Ziegler, P. Bartenstein, E. Wagner, P. Nelson, C. Spitzweg   +15 more
semanticscholar   +1 more source

Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma

Molecular Therapy: Oncolytics, 2022
Sodium iodide symporter (NIS) gene transfer for active accumulation of iodide in tumor cells is a powerful theranostic strategy facilitating both diagnostic and therapeutic application of radioiodide.
Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Mara Hageneier, Nathalie Schwenk, Özgür Öztürk, K. Steiger, G. Multhoff, M. Eiber, F. Schilling, W. Weber, R. Kälin, R. Glass, P. Nelson, E. Wagner, C. Spitzweg   +15 more
semanticscholar   +1 more source

Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes

Thyroid, 2022
Background: The sodium/iodide symporter (NIS) is a transmembrane protein located on the basolateral membrane of thyrocytes. Despite its physiological and clinical relevance, little is known about the mechanisms that mediate NIS subcellular sorting.
P. Koumarianou, C. Fernández-Méndez, Dánae Fajardo-Delgado, L. M. Mielu, P. Santisteban, A. de la Vieja   +5 more
semanticscholar   +1 more source

Mechanisms of Sodium/Iodide Symporter-Mediated Mammary Gland Iodine Compensation during Lactation

Nutrients, 2022
This research aimed to investigate the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. Female rats were divided into the low iodine group (LI), the normal iodine group (NI), the 10-fold high iodine group ...
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang   +8 more
semanticscholar   +1 more source

Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells

Cells, 2022
The transcription factor CREB3L1 is expressed in a wide variety of tissues including cartilage, pancreas, and bone. It is located in the endoplasmic reticulum and upon stimulation is transported to the Golgi where is proteolytically cleaved.
Pablo Di Giusto, Mariano Martín, Macarena Funes Chabán, Luciana Sampieri, J. Nicola, C. Alvarez   +5 more
semanticscholar   +1 more source