Results 11 to 20 of about 823 (135)

The extra-thyroidal distribution of sodium iodide symporter [PDF]

Frontiers in Endocrinology
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells. Iodine is an essential molecule that is used to produce the classical thyroid hormones that contribute to growth and development of various parts of the body and play a ...
Strinivasen Naidoo, Meleshni Naicker
exaly   +5 more sources

Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor. [PDF]

Birth Defects Res
ABSTRACT Background Fluoride has come under recent scrutiny regarding concerns over potential neurodevelopmental and endocrine‐related toxicities, with recent reviews by the National Toxicology Program (NTP) and European Food Safety Authority (EFSA) concluding with moderate or reasonable confidence, respectively, that exposure to drinking water having ...
Mudd AM, Ovando BJ, Daston GP.
europepmc   +2 more sources

Molecular Traces of Gastric Cancer in Saliva: From Tissue Signatures to Salivary SLC5A5 as a Potential Biomarker. [PDF]

United European Gastroenterol J
ABSTRACT Background Early detection of gastric cancer (GC) and reliable risk stratification for metachronous gastric lesions (MGLs) remain societal and clinical challenges, particularly in intermediate risk populations. Non‐invasive approaches such as saliva‐based biomarkers could complement current strategies. The aim of this study was to identify and
Lopes C, Brandão A, Vavoulis D, Paulino S, Costa J, de Sá IM, Archer S, Küttner-Magalhães R, Marcos-Pinto R, Libânio D, Dinis-Ribeiro M, Pereira C.   +11 more
europepmc   +2 more sources

Anion Selectivity by the Sodium Iodide Symporter [PDF]

Endocrinology, 2003
Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline, Massart, Claude, Beauwens, Renaud, Schoutens, André, Costagliola, Sabine, Dumont, Jacques Emile, Wolff, J   +6 more
openaire   +3 more sources

Dimerization of the Sodium/Iodide Symporter

Thyroid®, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson, Rebecca J., Fletcher, Alice, Brookes, Katie, Nieto, Hannah, Alshahrani, Mohammed M., Mueller, Jonathan W., Fine, Nicholas H.F., Hodson, David J., Boelaert, Kristien, Read, Martin L., Smith, Vicki E., McCabe, Christopher J.   +11 more
openaire   +2 more sources

Expression of the sodium iodide symporter in human kidney [PDF]

Kidney International, 2001
The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Spitzweg, Christine, Dutton, Charyl M., Castro, Maria R., Bergert, Elizabeth R., Goellner, John R., Heufelder, Armin E., Morris, John C.   +6 more
openaire   +2 more sources

Dual Reporter Gene Imaging

Molecular Imaging, 2005
The human and rodent sodium iodide symporters ( NIS ) have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked human NIS (
Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg   +5 more
doaj   +1 more source

Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]

Hormones and Cancer, 2014
Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Aparna, Lakshmanan, Daniel, Scarberry, Daniel H, Shen, Sissy M, Jhiang   +3 more
openaire   +2 more sources

Sodium Iodide Symporter (NIS) and Thyroid

HORMONES, 2002
idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine, Spitzweg, John C, Morris
openaire   +2 more sources

Post-transcriptional Regulation of the Sodium/Iodide Symporter by Thyrotropin [PDF]

Journal of Biological Chemistry, 2001
The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active I(-) transport in the thyroid gland (Dai, G., Levy, O., and Carrasco, N. (1996) Nature 379, 458-460), the first step in thyroid hormone biogenesis. Whereas relatively little is known about the mechanisms by which thyrotropin (TSH), the main hormonal regulator of ...
C, Riedel, O, Levy, N, Carrasco
openaire   +2 more sources