Results 1 to 10 of about 16,105 (218)

Prokaryotic Solute/Sodium Symporters: Versatile Functions and Mechanisms of a Transporter Family

International Journal of Molecular Sciences, 2021
The solute/sodium symporter family (SSS family; TC 2.A.21; SLC5) consists of integral membrane proteins that use an existing sodium gradient to drive the uphill transport of various solutes, such as sugars, amino acids, vitamins, or ions across the ...
Tania Henriquez, Larissa Wirtz, Dan Su   +2 more
exaly   +3 more sources

Dual Reporter Gene Imaging

Molecular Imaging, 2005
The human and rodent sodium iodide symporters ( NIS ) have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked human NIS (
Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg   +5 more
doaj   +3 more sources

The extra-thyroidal distribution of sodium iodide symporter. [PDF]

Front Endocrinol (Lausanne)
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Gadisi RP, Naicker M, Naidoo S.
europepmc   +5 more sources

Failure of Membrane Targeting Causes the Functional Defect of Two Mutant Sodium Iodide Symporters

Journal of Clinical Endocrinology and Metabolism, 2000
Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect. Whereas various mutant human (h) NIS molecules display loss of function when expressed by transfection in ...
Joachim Pohlenz
exaly   +3 more sources

The sodium/iodide symporter: State of the art of its molecular characterization

Biochimica Et Biophysica Acta - Biomembranes, 2014
The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and thyroid regulation and its function is widely exploited in the ...
Elisabeth Darrouzet, Jean-Luc Pellequer, Thierry Pourcher   +2 more
exaly   +3 more sources

Combined Vorinostat and Chloroquine Inhibit Sodium-Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo. [PDF]

Clin Cancer Res, 2023
Purpose Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization of the sodium/iodide symporter (NIS).
Read ML, Brookes K, Zha L, Manivannan S, Kim J, Kocbiyik M, Fletcher A, Gorvin CM, Firth G, Fruhwirth GO, Nicola JP, Jhiang S, Ringel MD, Campbell MJ, Sunassee K, Blower PJ, Boelaert K, Nieto HR, Smith VE, McCabe CJ.   +19 more
europepmc   +2 more sources

Structural insights into the mechanism of the sodium/iodide symporter (NIS)

Yearbook of Paediatric Endocrinology, 2022
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I − ) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones—the master regulators of intermediary metabolism ...
S. Ravera, J. Nicola, Glicella Salazar-De Simone, F. Sigworth, E. Karakas, L. Amzel, M. Bianchet, N. Carrasco   +7 more
semanticscholar   +3 more sources

Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography. [PDF]

Eur J Nucl Med Mol Imaging
Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human epidermal growth factor receptor 2 (HER2).
Shalaby N, Xia Y, Kelly JJ, Sanchez-Pupo R, Martinez F, Fox MS, Thiessen JD, Hicks JW, Scholl TJ, Ronald JA.   +9 more
europepmc   +2 more sources

Anion Selectivity by the Sodium Iodide Symporter [PDF]

Endocrinology, 2003
Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline, Massart, Claude, Beauwens, Renaud, Schoutens, André, Costagliola, Sabine, Dumont, Jacques Emile, Wolff, J   +6 more
openaire   +3 more sources

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Theranostics, 2021
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane,
J. Oh, B. Ahn
semanticscholar   +1 more source