Results 31 to 40 of about 16,105 (218)
Molecular Therapy: Oncolytics, 2021 Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful
Rebekka Spellerberg +14 more
semanticscholar +1 more source
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter
Cell Chemical Biology, 2021 Summary The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogenic ...
Martin L Read +14 more
semanticscholar +1 more source
Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism
Thyroid, 2021 The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.
H. Durgia +7 more
semanticscholar +1 more source
Sodium Iodide Symporter (NIS) and Thyroid
HORMONES, 2002 idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine, Spitzweg, John C, Morris
openaire +2 more sources
Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution
, 2022 Sodium-coupled neurotransmitter transporters play a fundamental role in the termination of synaptic neurotransmission, which makes them a major drug target.
Loland, Claus J. +2 more
core +1 more source
Frontiers in Oncology, 2021 The dedifferentiation of differentiated thyroid cancer (DTC) is a challenging problem for radioactive iodine (131I) treatment, also known as radioiodine refractory differentiated thyroid cancer (RAIR-DTC). The purpose of this study was to further explore
Shasha Hou +7 more
semanticscholar +1 more source
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
, 2007 Background: The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Matouskova, M +8 more
core +1 more source
Post-transcriptional Regulation of the Sodium/Iodide Symporter by Thyrotropin [PDF]
Journal of Biological Chemistry, 2001 The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active I(-) transport in the thyroid gland (Dai, G., Levy, O., and Carrasco, N. (1996) Nature 379, 458-460), the first step in thyroid hormone biogenesis. Whereas relatively little is known about the mechanisms by which thyrotropin (TSH), the main hormonal regulator of ...
C, Riedel, O, Levy, N, Carrasco
openaire +2 more sources
Mechanistic aspects of sodium-binding sites in LeuT-like fold symporters [PDF]
, 2013 Secondary active transporters are of paramount biological impact in all living cells, facilitating the movement of many different substrates across the membrane against a concentration gradient.
Ziegler, Christine +3 more
core +1 more source
Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]
Clinical Cancer Research, 2004 Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Elena, Mitrofanova +7 more
openaire +2 more sources