Results 71 to 80 of about 16,105 (218)

Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.

European Journal of Endocrinology, 2020
Objective Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).
A. Eleftheriadou, S. Mehl, K. Renko, Rega H. Kasim, Jasmin Schaefer, W. Minich, L. Schomburg   +6 more
semanticscholar   +1 more source

Bioinspired Microreactor for Iodide Adsorption and Photooxidation Recovery

Advanced Science, Volume 13, Issue 23, 23 April 2026.
A bioinspired micro‐ionic‐reactor based on porous organic polymer (MIR‐POP) integrates rapid iodide capture with in situ photooxidative conversion, achieving record uptake capacity and high uptake efficiencies in simulated mining wastewater and natural brine. This bioinspired microreactor strategy offers a new avenue for sustainable iodine recovery and
Xuewen Cao, Xuefeng Tian, Jun Zhang, Jinjiao Pan, Rui Huang, Xinfeng Du, Yihui Yuan, Ning Wang, Hui Wang   +8 more
wiley   +1 more source

Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells

Journal of Cancer, 2020
Objective: Anaplastic thyroid cancer/ATC is a highly aggressive malignancy with extremely poor prognosis. Resveratrol/Res promotes re-differentiation of cancer cells and exerts inhibitory effects on ATC cells.
Le Xiong, Jun-Hua Nie, Xiao-Min Lin, Jian-Bin Wu, Zhen Chen, Bo Xu, Jia Liu   +6 more
semanticscholar   +1 more source

Association of Urinary Perchlorate and Thiocyanate With Cognitive Function in Older Adults: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims It is well‐known that perchlorate, nitrate, and thiocyanate are thyroid‐disrupting chemicals. Evidence regarding the cognitive correlates of thyroid‐disrupting anions in older adults remains scarce, particularly in population‐based studies assessing multiple cognitive domains.
Qi Gao, Zhenjie Sun, Yanfeng Wang
wiley   +1 more source

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells

Journal of experimental & clinical cancer research : CR, 2019
Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating Graves’ disease and thyroid cancer.
W. Chai, Fanghua Ye, L. Zeng, Yanling Li, Liangchun Yang   +4 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Da Mu, Suping Li, Rui Huang, Anren Kuang, Xiaojuan Ma   +4 more
core  

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter [PDF]

, 2016
Neurotransmitter/sodium symporters (NSSs) are responsible for Na(+)-dependent reuptake of neurotransmitters and represent key targets for antidepressants and psychostimulants.
Loland, Claus J, Mortensen, Jonas S, Billesbølle, Christian B, Sitte, Harald H, Mortensen, Jonas S., Billesbølle, Christian B., Loland, Claus J., Schmidt, Solveig G., Sohail, Azmat, Shi, Lei, Sitte, Harald H., Schmidt, Solveig Gaarde, Gether, Ulrik   +12 more
core   +1 more source

Tumor microenvironment affects exogenous sodium/iodide symporter expression

Translational Oncology, 2020
Highlights • NIS-expressing xenografts show low iodide uptake in areas exhibiting hypoperfusion.• NIS subcellular localization and NIS expression is impaired under quiescent and/or hypoxic states.• Proteomics and metabolomics reveal tumor ...
Fabio Castillo-Rivera, Alejandro Ondo-Méndez, J. Guglielmi, J. Guigonis, Lun Jing, S. Lindenthal, Andrea Gonzalez, D. López, B. Cambien, T. Pourcher   +9 more
semanticscholar   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source