Results 91 to 100 of about 823 (135)

Sodium/iodide symporter (NIS) and cytokines

Experimental and Clinical Endocrinology & Diabetes, 2001
It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1beta and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells.
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Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid, 2017
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.The study employed ...
Schmohl, Kathrin A, Dolp, Patrick, Schug, Christina, Knoop, Kerstin, Klutz, Kathrin, Schwenk, Nathalie, Bartenstein, Peter, Nelson, Peter J, Ogris, Manfred, Wagner, Ernst, Spitzweg, Christine   +10 more
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Implications of the molecular characterization of the sodium-iodide symporter (NIS)

Experimental and Clinical Endocrinology & Diabetes, 2009
The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient. This uptake requires energy, is coupled to the action of Na+/K+-ATPase, and stimulated by TSH, the main hormone regulating thyroid-specific ...
C, Schmutzler, J, Köhrle
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Regulation of the sodium/iodide symporter by retinoids - a review

Experimental and Clinical Endocrinology & Diabetes, 2001
Decrease or loss of iodide uptake, due to impaired expression and/or function of the sodium/iodide-symporter (NIS), is a major obstacle to the treatment of advanced thyroid carcinomas by radioiodide therapy. Several approaches are being evaluated to optimise or restore sufficient iodide transport in those cases, among them retinoid therapy.
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Small‐Molecule Inhibitors of Sodium Iodide Symporter Function

ChemBioChem, 2008
Abstract The Na + /I − symporter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post‐translational ...
Nathalie, Lecat-Guillet, Goulven, Merer, Roman, Lopez, Thierry, Pourcher, Bernard, Rousseau, Yves, Ambroise   +5 more
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Gene therapy with sodium/iodide symporter in hepatocarcinoma

Experimental and Clinical Endocrinology & Diabetes, 2001
The ability of thyroid cells to accumulate iodide is a prerequisite for successful radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence
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In vivo imaging and tumor therapy with the sodium iodide symporter

Journal of Cellular Biochemistry, 2003
AbstractThere has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and ...
David, Dingli, Stephen J, Russell, John C, Morris   +2 more
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A systematic evaluation of sorting motifs in the sodium–iodide symporter (NIS)

Biochemical Journal, 2016
The sodium–iodide symporter (NIS) is an integral membrane protein that plays a crucial role in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its intracellular sorting and distribution have a tremendous effect on its function, and constitute an important aspect of its regulation.
Darrouzet, E., Graslin, F., Marcellin, D., Tcheremisinova, I., Marchetti, C., Salleron, L., Pognonec, P., Pourcher, T.   +7 more
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Sodium Iodide Symporter and Pendrin Expression in Human Thyroid Tissues

Thyroid, 2001
Thyroid cells synthesize thyroid hormones through a multistep process during which iodide is transported through the basolateral and the apical membranes of thyrocytes. Two genes that participate in these transports and the corresponding proteins, namely sodium iodide symporter (NIS) and pendrin, the product of the Pendred syndrome gene, have recently ...
MIAN, CATERINA, LACROIX L, ALZIEU L, NOCERA M, TALBOT M, BIDART JM, SCHLUMBERGER M, CAILLOU B.   +7 more
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Sodium Iodide Symporter (NIS) Gene Expression in Human Placenta

Placenta, 2001
The placenta must allow the passage of iodide from the maternal to the fetal circulation for synthesis of thyroxine by the fetal thyroid. The thyroid sodium iodide symporter (NIS) was cloned in 1996 and, although widely distributed among epithelial tissues, early studies failed to detect it in placenta. We demonstrated NIS mRNA in human placenta and in
Mitchell, AM, Manley, SW, Morris, JC, Powell, KA, Bergert, ER, Mortimer, RH   +5 more
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