Results 91 to 100 of about 16,105 (218)
The neurotransmitter sodium symporters (NSSs) play critical roles in the neurotransmission of monoamine and amino acid neurotransmitters and are the molecular targets of therapeutic agents in the treatment of several psychiatric disorders.
Yanhong Xu +4 more
core +1 more source
, 2020 Glomerular hyperfiltration is a common finding in patients with diabetes and poor glycemic control; whole-kidney hyperfiltration, with glomerular filtration rate (GFR) values above normal, should be differentiated from single nephron hyperfiltration ...
Marta Mazzucato +5 more
core +1 more source
Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica [PDF]
, 2014 Rhodopirellula baltica (R. baltica) is a Planctomycete, known to have intracellular membranes. Because of its unusual cell structure and ecological significance, we have conducted comprehensive analyses of its transmembrane transport proteins.
Paparoditis, Philipp +7 more
core +1 more source
Environment International, 2019 In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang +7 more
semanticscholar +1 more source
Homology of pendrin sodium-iodide symporter and apical iodide transporter
Frontiers in Bioscience, 2018 We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins.
Benvenga, Salvatore, Guarneri, Fabrizio
openaire +3 more sources
Redifferentiation Therapies in Thyroid Oncology: Molecular and Clinical Aspects
Since the 1940s, 131-I radioiodine therapy (RIT) has been the primary treatment for metastatic differentiated thyroid cancer (DTC). Approximately half of these patients respond favorably to RIT, achieving partial or complete remission or maintaining long-
Petra Petranović Ovčariček +10 more
core +1 more source
Translational Research Using Sodium/Iodide Symporter
Journal of Korean Endocrine Society, 2006 184 1915년에 갑상선 조직에 요오드가 선택적으로 축적된다 는 사실이 밝혀졌고, 그 이후 갑상선 질환의 진단과 치료에 방사성요오드가 널리 이용되게 되었다. 갑상선 조직은 요오 드를 혈액에서부터 20~40배 정도 높은 농도로 축적한다. 약 60년 전부터 방사성요오드를 갑상선 기능을 측정하는 추적 자로 사용하였고, 곧이어 갑상선기능항진증과 갑상선암에서 I-131를 치료제로 사용하게 되었다. 그러나 갑상선 세포에 요오드가 선택적으로 섭취되는 기 전은 최근에야 밝혀졌다.
June-Key Chung, Joo Hyun Kang
openaire +1 more source
Structural basis for substrate binding and specificity of a sodium–alanine symporter AgcS [PDF]
, 2019 The amino acid, polyamine, and organocation (APC) superfamily is the second largest superfamily of membrane proteins forming secondary transporters that move a range of organic molecules across the cell membrane.
Sanchez-Martinez, Silvia +6 more
core +1 more source
, 2015 The cyclic polyol myo-inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain.
Schneider, Sabine
core +1 more source