Results 161 to 170 of about 16,105 (218)

Ingested nitrate and nitrite, drinking water disinfection by-products, and incidence of thyroid cancer among licensed pesticide applicators and spouses in the Agricultural Health Study. [PDF]

Ecotoxicol Environ Saf
Chen D, Parks CG, Beane Freeman LE, Hofmann JN, Spaur M, Madrigal JM, Sinha R, Jones RR, Ward MH, Sandler DP.   +9 more
europepmc   +1 more source

Renal and small-intestinal sodium-dependent symporters of phosphate and sulfate

, 1994
Biber, Juerg, Markovich, Daniel, Murer, Heini   +2 more
core  

Functional identification and characterization of sodium binding sites in Na symporters [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2013
Sodium cotransporters from several different gene families belong to the leucine transporter (LeuT) structural family. Although the identification of Na(+) in binding sites is beyond the resolution of the structures, two Na(+) binding sites (Na1 and Na2)
Donald D F Loo, Bruce A Hirayama, Ernest M Wright   +2 more
exaly   +2 more sources

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High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter.

Chemical Research in Toxicology, 2023
Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic-pituitary-thyroid axis to potentially disrupt thyroid synthesis, transport, metabolism, and/or function.
T. Stoker, Jun Wang, A. Murr, J. R. Bailey, A. Buckalew   +4 more
semanticscholar   +1 more source

Chloride binding site of neurotransmitter sodium symporters

Proceedings of the National Academy of Sciences of the United States of America, 2013
Matthias Quick, Lei Shi, Anne-Marie Lund Winther   +2 more
exaly   +2 more sources

The Sodium-Iodide Symporter

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2004
The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
C H, Baker, J C, Morris
openaire   +2 more sources

Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via suppression of the PI3K-AKT signaling pathway.

Food & Function, 2021
Radioactive iodine (RAI) is commonly used to treat differentiated thyroid cancer (DTC). A major challenge is the dedifferentiation of DTC with the loss of radioiodine uptake.
Li Zhang, Shichen Xu, Xian Cheng, Jing Wu, Xiaowen Wang, Liying Wu, Huixin Yu, Jiandong Bao   +7 more
semanticscholar   +1 more source

Cloning of the Mouse Sodium Iodide Symporter

Thyroid, 2001
The iodide-concentrating ability of the thyroid gland is essential to the production of thyroid hormone. We report the nucleotide and amino acid sequence of the mouse sodium iodide symporter (mNIS), which mediates this activity within the thyroid gland.
L A, Pinke, D S, Dean, E R, Bergert, C, Spitzweg, C M, Dutton, J C, Morris   +5 more
openaire   +2 more sources

Sodium Iodide Symporter in Health and Disease

Thyroid, 2001
Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy.
D H, Shen, R T, Kloos, E L, Mazzaferri, S M, Jhian   +3 more
openaire   +2 more sources