Results 171 to 180 of about 16,105 (218)

The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane

The FASEB Journal, 2021
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis.
Mariano Martín, L. Salleron, Victoria Peyret, R. C. Geysels, E. Darrouzet, S. Lindenthal, Carlos Eduardo Bernal Barquero, A. Masini-Repiso, T. Pourcher, J. Nicola   +9 more
semanticscholar   +1 more source

Sodium/iodide symporter in thyroid cancer

Experimental and Clinical Endocrinology & Diabetes, 2001
[No abstract available]
C. Mian, L. Lacroix, J. M. Bidart, B. Caillou, FILETTI, SEBASTIANO, M. Schlumberger   +5 more
openaire   +4 more sources

Impact of the Mutational Landscape of the Sodium/Iodide Symporter in Congenital Hypothyroidism

Thyroid, 2021
Background: Iodide transport defect is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient ...
Mariano Martín, J. Nicola
semanticscholar   +1 more source

Approaches to gene therapy with sodium/iodide symporter

Experimental and Clinical Endocrinology & Diabetes, 2001
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy.
C, Spitzweg, J C, Morris
openaire   +2 more sources

Identification of a Second Substrate-binding Site in Solute-Sodium Symporters

Journal of Biological Chemistry, 2015
Heinrich Jung, Aviv Paz, Jay Prakash Kumar   +2 more
exaly   +2 more sources

Expression of the Sodium/Iodide Symporter in Human Prostate Adenocarcinoma

Urology, 2010
To analyze expression of the sodium/iodide symporter (NIS) in tissue specimen from a large series of patients with prostate adenocarcinoma. Few data are available on the NIS expression in prostate tumor tissues.NIS protein expression was examined by immunohistochemistry in 78 tumor tissue specimen and their non-neoplastic counterparts.
M. Navarra, MICALI, Salvatore, SM lepore, AM Cesinaro, M. Celano, MC Sighinolfi, C. De Gaetani, S. Filetti, BIANCHI, Giampaolo, D. Russo   +9 more
openaire   +3 more sources

Sodium/iodide symporter (NIS) and cytokines

Experimental and Clinical Endocrinology & Diabetes, 2001
It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1beta and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells.
openaire   +2 more sources

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid, 2017
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.The study employed ...
Schmohl, Kathrin A, Dolp, Patrick, Schug, Christina, Knoop, Kerstin, Klutz, Kathrin, Schwenk, Nathalie, Bartenstein, Peter, Nelson, Peter J, Ogris, Manfred, Wagner, Ernst, Spitzweg, Christine   +10 more
openaire   +3 more sources

A Novel Tyrosine Kinase Inhibitor Can Augment Radioactive Iodine Uptake Through Endogenous Sodium/Iodide Symporter Expression in Anaplastic Thyroid Cancer

Thyroid, 2020
Background: Radioactive iodine (RAI) therapy is an important strategy in the treatment of thyroid cancer. However, anaplastic thyroid cancer (ATC), a rare malignancy, exhibits severe dedifferentiation characteristics along with a lack of sodium iodide ...
J. Oh, S. Baek, Prakash Gangadaran, C. Hong, R. Rajendran, Ho Won Lee, Liya Zhu, Arunnehru Gopal, Senthilkumar Kalimuthu, S. Jeong, Sang-Woo Lee, Jaetae Lee, B. Ahn   +12 more
semanticscholar   +1 more source

Implications of the molecular characterization of the sodium-iodide symporter (NIS)

Experimental and Clinical Endocrinology & Diabetes, 2009
The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient. This uptake requires energy, is coupled to the action of Na+/K+-ATPase, and stimulated by TSH, the main hormone regulating thyroid-specific ...
C, Schmutzler, J, Köhrle
openaire   +2 more sources