Results 181 to 190 of about 16,105 (218)

Regulation of the sodium/iodide symporter by retinoids - a review

Experimental and Clinical Endocrinology & Diabetes, 2001
Decrease or loss of iodide uptake, due to impaired expression and/or function of the sodium/iodide-symporter (NIS), is a major obstacle to the treatment of advanced thyroid carcinomas by radioiodide therapy. Several approaches are being evaluated to optimise or restore sufficient iodide transport in those cases, among them retinoid therapy.
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Small‐Molecule Inhibitors of Sodium Iodide Symporter Function

ChemBioChem, 2008
Abstract The Na + /I − symporter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post‐translational ...
Nathalie, Lecat-Guillet, Goulven, Merer, Roman, Lopez, Thierry, Pourcher, Bernard, Rousseau, Yves, Ambroise   +5 more
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Gene therapy with sodium/iodide symporter in hepatocarcinoma

Experimental and Clinical Endocrinology & Diabetes, 2001
The ability of thyroid cells to accumulate iodide is a prerequisite for successful radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence
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In vivo imaging and tumor therapy with the sodium iodide symporter

Journal of Cellular Biochemistry, 2003
AbstractThere has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and ...
David, Dingli, Stephen J, Russell, John C, Morris   +2 more
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A systematic evaluation of sorting motifs in the sodium–iodide symporter (NIS)

Biochemical Journal, 2016
The sodium–iodide symporter (NIS) is an integral membrane protein that plays a crucial role in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its intracellular sorting and distribution have a tremendous effect on its function, and constitute an important aspect of its regulation.
Darrouzet, E., Graslin, F., Marcellin, D., Tcheremisinova, I., Marchetti, C., Salleron, L., Pognonec, P., Pourcher, T.   +7 more
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Sodium Iodide Symporter and Pendrin Expression in Human Thyroid Tissues

Thyroid, 2001
Thyroid cells synthesize thyroid hormones through a multistep process during which iodide is transported through the basolateral and the apical membranes of thyrocytes. Two genes that participate in these transports and the corresponding proteins, namely sodium iodide symporter (NIS) and pendrin, the product of the Pendred syndrome gene, have recently ...
MIAN, CATERINA, LACROIX L, ALZIEU L, NOCERA M, TALBOT M, BIDART JM, SCHLUMBERGER M, CAILLOU B.   +7 more
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Sodium Iodide Symporter (NIS) Gene Expression in Human Placenta

Placenta, 2001
The placenta must allow the passage of iodide from the maternal to the fetal circulation for synthesis of thyroxine by the fetal thyroid. The thyroid sodium iodide symporter (NIS) was cloned in 1996 and, although widely distributed among epithelial tissues, early studies failed to detect it in placenta. We demonstrated NIS mRNA in human placenta and in
Mitchell, AM, Manley, SW, Morris, JC, Powell, KA, Bergert, ER, Mortimer, RH   +5 more
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Characterization of the upstream enhancer of the rat sodium/iodide symporter gene

Experimental and Clinical Endocrinology & Diabetes, 2001
We previously demonstrated the presence of an enhancer that is located between nucleotides - 2264 and - 2495 in the 5' flanking region of the rat sodium/iodide symporter (NIS) gene (Ohno et al., 1999). When attached to NIS or heterologous promoters, this 232 bp fragment, which we call NUE, is able to stimulate transcription in a thyroid-specific and ...
CHUN J. T., DI LAURO, ROBERTO
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Sodium Iodide Symporter in the Fight Against Thyroid Cancer

Future Oncology, 2013
n radioiodide n signal transduction inhibitor n sodium iodide symporter n thyroid cancer More than 60 years of experience of radioiodide therapy has indicated its usefulness for the treatment of differentiated thyroid cancer. This therapy utilizes the differentiated function of thyroid cells, namely iodide uptake for thyroid hormone synthesis.
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Visualisation of sodium-iodide symporter

European Journal of Nuclear Medicine and Molecular Imaging, 2005
Montserrat, Estorch, Luis, de Andres, Valle, Camacho, Jordi, Fuertes, Ato, Rodriguez, Albert, Flotats, Ignasi, Carrio   +6 more
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