Neural Regeneration Research, 2019 Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.
Chaoyang Tan +12 more
semanticscholar +1 more source
The Potassium Transporter Hak1 in Candida Albicans, Regulation and Physiological Effects at Limiting Potassium and under Acidic Conditions [PDF]
, 2021 The three families of yeast plasma membrane potassium influx transporters are represented in Candida albicans: Trk, Acu, and Hak proteins. Hak transporters work as K+-H+ symporters, and the genes coding for Hak proteins are transcriptionally activated ...
Michán, Carmen +3 more
core +1 more source
Scientific Reports, 2018 The Na+–K+–2Cl− cotransporter NKCC1 plays a role in neuronal Cl− homeostasis secretion and represents a target for brain pathologies with altered NKCC1 function. Two main variants of NKCC1 have been identified: a full-length NKCC1 transcript (NKCC1A) and
Philip Hampel +3 more
semanticscholar +1 more source
Oncology Letters, 2016 Peritumoral edema is a key stage in the infiltration and recurrence of glioma. Photodynamic therapy (PDT) increases the extent of peritumoral edema, which leads to a decrease in the effectiveness of PDT in treating glioma. The present study evaluated the
Bo Li +7 more
semanticscholar +1 more source
Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases
Current Neuropharmacology, 2015 Sodium potassium chloride co-transporter (NKCC) belongs to cation-dependent chloride co-transporter family, whose activation allows the entry of Na+, K+ and 2Cl- inside the cell.
A. Jaggi +3 more
semanticscholar +1 more source
bloated tubules (blot) Encodes a Drosophila Member of the Neurotransmitter Transporter Family Required for Organisation of the Apical Cytocortex [PDF]
, 1999 We have identified a novel member of the vertebrate sodium- and chloride-dependent neurotransmitter symporter family from Drosophila melanogaster. This gene, named bloated tubules (blot), shows significant sequence similarity to a subgroup of vertebrate ...
Johnson, Kevin +2 more
core +1 more source
A theoretical approach for the electrochemical characterization of ciliary epithelium [PDF]
, 2020 The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion.
Bonifazi, G. +7 more
core +1 more source
The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]
, 2011 Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y. +2 more
core +2 more sources
Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: a candidate for cystic fibrosis therapy [PDF]
, 2018 Cystic fibrosis (CF) is a genetic lethal disease, originated from the defective function of the CFTR protein, a chloride and bicarbonate permeable transmembrane channel.
Baroni, Debora +7 more
core +2 more sources
Threonine 67 is a key component in the coupling of the NSS amino acid transporter KAAT1 [PDF]
, 2018 The crystallizations of the prokaryotic LeuT and of the eukaryotic DAT and SERT transporters represent important steps forward in the comprehension of the molecular physiology of Neurotransmitter: Sodium Symporters, although the molecular determinants of
A. Vollero +6 more
core +1 more source