Results 1 to 10 of about 4,001 (111)
Impact of hyperbilirubinemia on rat cardiomyocyte injury [PDF]
BMC Cardiovascular DisordersBackground To investigate bilirubin-induced injury in rat myocardial cells at varying concentrations. Methods The study utilized the rat cardiomyocyte cell line H9C2 and primary rat cardiomyocytes. Bilirubin-rich and control sera were prepared, and cells
Jiajia Zhao +5 more
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Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis
Frontiers in Aging Neuroscience, 2022 Vascular dementia (VaD) is the second most common cause of cognitive impairment amongst the elderly. However, there are no known disease-modifying therapies for VaD, probably due to incomplete understanding of the molecular basis of the disease.
Sasha A. Philbert +7 more
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The Effects of Altered Membrane Cholesterol Levels on Sodium Pump Activity in Subclinical Hypothyroidism [PDF]
Endocrinology and Metabolism, 2017 BackgroundMetabolic dysfunctions characteristic of overt hypothyroidism (OH) start at the early stage of subclinical hypothyroidism (SCH). Na+/K+-ATPase (the sodium pump) is a transmembrane enzyme that plays a vital role in cellular activities in ...
Suparna Roy, Anindya Dasgupta
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Oxidant/antioxidant status in Type-2 diabetes mellitus patients with metabolic syndrome
Journal of Research in Medical Sciences, 2021 Background: The concurrence of metabolic syndrome (MS) and diabetes mellitus (DM) is increasing worldwide. The long-term complications of these chronic diseases are a threat to patients' well-being.
Ali Najafi +2 more
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ATP1A3-Related Disorders: An Ever-Expanding Clinical Spectrum
Frontiers in Neurology, 2021 The Na+/K+ ATPases are Sodium-Potassium exchanging pumps, with a heteromeric α-β-γ protein complex. The α3 isoform is required as a rescue pump, after repeated action potentials, with a distribution predominantly in neurons of the central nervous system.
Philippe A. Salles +5 more
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Frontiers in Aging Neuroscience, 2022 Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the ...
Sasha A. Philbert +7 more
doaj +1 more source
Effects of Sodium-Potassium-Exchanging ATPase and Nitric Oxide on Ethanol Induced Relaxations
Turkiye Klinikleri Journal of Medical Sciences, 2017 Objective: Alcohol is widely used in the world and can cause gastrointestinal (GI) disturbances. Elucidating the molecular mechanism of alcohol in the GI tract may contribute to the therapeutic approaches on GI diseases caused by alcohol. So in the present study we aimed to elucidate the molecular mechanism of ethanol on isolated mouse gastric fundus ...
Derya KAYA, Naciye YAKTUBAY DÖNDAŞ
openaire +2 more sources
Journal of Research in Medical Sciences, 2019 Background: Na+/K+ ATPase enzyme is essential for nerve cell membrane integrity, and reduction in its activity, probably due to ATP1A1 gene polymorphisms, is related to diabetic neuropathy progression.
Mohammed A Abosheasha +4 more
doaj +1 more source
“Oxygen sensing” by Na,K-ATPase: these miraculous thiols
Frontiers in Physiology, 2016 Control over the Na,K-ATPase function plays a central role in adaptation of the organisms to hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its oxygen-sensitivity is mediated by a variety of redox-sensitive ...
Anna Bogdanova +4 more
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Frontiers in Computational Neuroscience, 2017 Changes in intracellular Na+ concentration ([Na+]i) are rarely taken into account when neuronal activity is examined. As opposed to Ca2+, [Na+]i dynamics are strongly affected by longitudinal diffusion, and therefore they are governed by the ...
Asaph Zylbertal +2 more
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