Results 141 to 150 of about 4,957,594 (400)

Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans [PDF]

open access: yes, 2013
Cardiac alternansis an important risk factor in cardiac physiology, and is related to the initiation of many pathophysiological conditions. However, the mechanisms underlying the generation of alternans remain unclear. In this study, we used a population
Bueno-Orovio, A.   +8 more
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

SODIUM ALUM. [PDF]

open access: yesJournal of the American Chemical Society, 1909
n ...
openaire   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Impact of Hyponatraemia at Clinical Stable-State on Survival in Patients with Chronic Obstructive Pulmonary Disease

open access: yesInternational Journal of COPD
Wang Chun Kwok,1 Desmond Yat Hin Yap,2 Terence Chi Chun Tam,1 David Chi Leung Lam,1 Mary Sau-Man Ip,1 James Chung Man Ho1 1Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong ...
Kwok WC   +5 more
doaj  

Features of the electrolyte distribution in various tissues in miniature pigs

open access: yesВавиловский журнал генетики и селекции, 2017
Striking similarities between human and miniature pig anatomy and physiology of the cardiovascular system, skin and digestive organs have made miniature pigs a successful animal model for addressing problems of xenotransplantation.
A. V. Fatianova   +3 more
doaj  

Effect of Salt Substitution on Cardiac Structure and ECG Parameters in Middle-aged and Elderly Hypertensive Patients

open access: yesReviews in Cardiovascular Medicine
Background: Salt substitution (SS) has been found to reduce blood pressure (BP). However, the impact of SS on cardiac structure, as assessed through ultrasonic cardiogram (UCG) and electrocardiograms (ECG), remains poorly understood ...
Li Che   +5 more
doaj   +1 more source

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