Results 121 to 130 of about 2,471,781 (316)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Key messages on sodium and sodium reduction [PDF]
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.CS323430Publication date from document properties.sodium-reduction-key-messages ...
core
Diclofenac sodium UV degradation [PDF]
, 2015 Diclofenac sodium (2- [2 - [(2,6-dicloro-fenil) amino] phenyl] sodium acetate) is an nonsteroidal antiinflammatory drug widely used today as an analgesic, anti-arthritic and anti-rheumatic. It is susceptible to stress caused by UV radiation. In this work
Sarno, María del Carmen Teresa +4 more
core
Screening 215 Lentil Genotypes under Salinity Stress During the Seedling Stage in Greenhouse Conditions [PDF]
پژوهشنامه اصلاح گیاهان زراعیExtended abstract Background: Salinity stress is one of the environmental stresses that significantly affects the growth of crops, especially in arid and semi-arid regions.
Ahmad Nezami +3 more
doaj
The epithelial sodium channel and the control of sodium balance
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010 Studies aiming at the elucidation of the genetic basis of rare monogenic forms of hypertension have identified mutations in genes coding for the epithelial sodium channel ENaC, for the mineralocorticoid receptor, or for enzymes crucial for the synthesis of aldosterone.
openaire +4 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Feasibility of Powerful EM Permanent Magnets Pumps for Sodium [PDF]
Method of theoretical calculation of magnetic field distribution for cylindrical magnetic rotor with Halbach array configuration of magnetic poles have been presented.
Šiško, Andrejs +3 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Skylab 3 Urinary Sodium Science Pilot [PDF]
, 1973 A graph of biomedical data for Urinary Sodium levels, for the Science Pilot of Skylab 3, Owen K ...
core