Results 111 to 120 of about 2,471,781 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Skylab 3 Urinary Sodium Commander [PDF]

, 1973
A graph of biomedical data for Urinary Sodium levels, for the Commander of Skylab 3, Alan L ...

core  

Poly[[tetramethanolbis[4-oxo-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-olato]disodium]–diethyl ether–methanol (1/1/2)]

IUCrData, 2016
In the title compound, [Na2(C16H7Cl3N5O2)2(CH3OH)4]·C4H10O·2CH3OH, the central pyrazolo[3,4-d]pyrimidine system makes dihedral angles of 82.98 (7)° with the trichlorophenyl ring and 13.11 (15)° with the pyridine ring.
Bassam Abu Thaher, Dieter Schollmeyer, Stefan Laufer   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Disturbances of sodium in critically ill adult neurologic patients: A clinical review [PDF]

, 2006
Disorders of sodium and water balance are common in critically ill adult neurologic patients. Normal aspects of sodium and water regulation are reviewed. The etiology of possible causes of sodium disturbance is discussed in both the general inpatient and
Watkiss, J, Crocker, M, Tisdall, M, Smith, M   +3 more
core  

Probing the calcium and sodium local environment in bones and teeth using multinuclear solid state NMR and X-ray absorption spectroscopy [PDF]

, 2010
Despite the numerous studies of bone mineral, there are still many questions regarding the exact structure and composition of the mineral phase, and how the mineral crystals become organised with respect to each other and the collagen matrix.
Newport, Robert J., Melinda, Duer, Smith, Mark E., Wojciech, Chrzanowski, Qiu, D., Robert, Newport, Knowles, J.C., Pickup, D.M., Duer, M.J., Dong, Qiu, Knowles, Jonathan, Wong, Alan, Knowles, Jonathan C., Qiu, Dong, Laurencin, D., Gan, Zhehong, Duer, Melinda J., Smith, M.E., Chrzanowski, W., David, Pickup, Laurencin, Danielle, Pickup, David M., Chrzanowski, Wojciech, Wong, A., Gan, Z.   +24 more
core   +1 more source

XAFS spectrum of Sodium chloride [PDF]

This dataset consists of X-ray absorption fine structure (XAFS) spectra at Cl K-edge of Sodium chloride measured at Ritsumeikan-SR BL-10, and is a part of XAFS database (MDR XAFS DB, https://doi.org/10.48505/nims.1447) as a collection of ...
Ritsumeikan SR Center
core   +3 more sources

Comparison of Urinary Sodium and Blood Pressure Relationship From the Spot Versus 24‐Hour Urine Samples

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We compared the relationship between sodium (Na) intake and blood pressure when Na intake was estimated from first‐ and second‐morning spot urine samples using the INTERSALT (International Study on Salt and Blood Pressure) formula, versus ...
Abu Mohd Naser, Mahbubur Rahman, Leanne Unicomb, Solaiman Doza, Shuchi Anand, Howard H. Chang, Stephen P. Luby, Thomas F. Clasen, K.M. Venkat Narayan   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effectiveness of a Self-monitoring Device for Urinary Sodium-to-Potassium Ratio on Dietary Improvement in Free-Living Adults: a Randomized Controlled Trial

Journal of Epidemiology, 2018
Background: Reducing the urinary sodium-to-potassium ratio is important for reducing both blood pressure and risk of cardiovascular disease. Among free-living Japanese individuals, we carried out a randomized trial to clarify the effect of lifestyle ...
Toshiyuki Iwahori, Hirotsugu Ueshima, Naoto Ohgami, Hideyuki Yamashita, Naoko Miyagawa, Keiko Kondo, Sayuki Torii, Katsushi Yoshita, Toshikazu Shiga, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura   +11 more
doaj   +1 more source