Results 101 to 110 of about 2,471,781 (316)
Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]
, 2008 Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G +12 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Systematic Review of Social Marketing as a Behavior Change Agent in Salt Reduction
Global HeartThe use of social marketing (SM) interventions for salt/sodium reduction has drawn increased attention worldwide. This systematic review investigates the application of social marketing principles to the design, implementation, and evaluation of salt ...
Silvia Sommariva +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Alloy Anode Materials for Sodium-Ion Batteries [PDF]
, 2013 Sodium-ion batteries could one day be an inexpensive alternative to lithium-ion batteries. Many challenges need to be overcome before commercialization of a sodium-ion battery can take place.
Ellis, Leah
core
Current Developments in NutritionBackground: High sodium intake is a major risk factor for noncommunicable diseases, with most Canadians exceeding recommended levels. Population-wide sodium-reduction interventions include monitoring sodium knowledge, attitudes, and behaviors as a core ...
Rola Al Ghali +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source