Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dietary sodium intake and all-cause mortality in kidney stone patients: a retrospective cohort study
Frontiers in NutritionBackgroundThe long-term effects of dietary sodium intake on patients with kidney stones remain unclear; hence, this study aims to investigate the correlation between dietary sodium intake and all-cause mortality in patients with kidney stones.MethodsThis
Shuangning Liu +5 more
doaj +1 more source
Concentration of Са2+, K+, Nа+ and their ratio in the Organa genitalia scrotum bovina
Біологічні студії, 2010 The research results indicate the presence of different concentrations in the scrotum tissue of Са2+ – 5–10, K+ – 42–181, Nа+ – 112–278 mM and their ratio of Nа+:Са2+ – 14–37:1, K+:Са2+ – 8–20:1 and Nа+:K+ – 1–4:1.
H. V. Maksymjuk
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Characterization of the sodium layer at Cerro Pachon, and impact on laser guide star performance
, 2013 Detailed knowledge of the mesopheric sodium layer characteristics is crucial to estimate and optimize the performance of Laser Guide Star (LGS) assisted Adaptive Optics (AO) systems.
Callingham, Joseph +5 more
core +1 more source
Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Synthesis of Rice Husk-Based Zeolit using Hydrothermal Method and Its Detergent Builder Properties [PDF]
, 2015 Detergents are cleaning agents that consist of a complex formulation such as surfactants, builders, bleaching, fillers and other additives.
Alfiansyah, A. +2 more
core +1 more source
NLTE determination of the sodium abundance in a homogeneous sample of extremely metal-poor stars [PDF]
, 2007 Abundance ratios in extremely metal-poor (EMP) stars are a good indication of the chemical composition of the gas in the earliest phases of the Galaxy evolution. It had been found from an LTE analysis that at low metallicity, and in contrast with most of
Andrievsky +38 more
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source