Antagonistic Effects of Sodium Butyrate and N-(4-Hydroxyphenyl)-retinamide on Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2007 Butyrates and retinoids are promising antineoplastic agents. Here we analyzed effects of sodium butyrate and N-(4-hydroxyphenyl)-retinamide (4-HPR) on prostate cancer cells as monotherapy or in combination in vitro and in vivo.
Rainer Kuefer +8 more
doaj +1 more source
A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome : results from a randomized double-blind placebo-controlled pilot trial [PDF]
, 2017 Background: Constipation and symptoms of gastrointestinal discomfort such as bloating are common among otherwise healthy individuals, but with significant impact on quality of life.
Marzorati, Massimo +6 more
core +1 more source
Laboratory Animal Research, 2016 We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus.
Hyo Young Jung +8 more
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Frontiers in Immunology, 2020 Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance ...
Jinjin Zhang +8 more
doaj +1 more source
Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study [PDF]
, 2016 The short-chain fatty acids (SCFAs), acetate, propionate and butyrate, are bacterial metabolites that mediate the interaction between the diet, the microbiota and the host.
Annaert, Pieter +12 more
core +1 more source
Brazilian Journal of Poultry Science, 2013 A 2 × 2 × 2 factorial arrangement was conducted to evaluate the effects of cereal type (corn vs. wheat), enzyme supplementation (0 or 0.4 g/kg diet), and sodium butyrate addition (0 or 2 g/kg diet) on growth performance, carcass traits and intestinal ...
MH Shahir +3 more
doaj +1 more source
In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria. [PDF]
, 2019 The objective of this study was to determine the in vitro antimicrobial activity of several organic acids and their derivatives against Gram-positive (G+) and Gram-negative (G-) bacteria.
Atwill, Edward Robert +8 more
core +1 more source
Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
Haematologica, 2010 Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels +4 more
doaj +1 more source
Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy. [PDF]
, 2016 Spinal muscular atrophy (SMA) is an early-onset motor neuron disease that leads to loss of muscle function. Butyrate (BA)-based compounds markedly improve the survival and motor phenotype of SMA mice.
Butchbach, Matthew E.R. +1 more
core +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Butyric acid plays an important role in maintaining intestinal health. Butyric acid has received special attention as a short-chain fatty acid, but its role in protecting the intestinal barrier is poorly characterized.
Wenqian Feng +8 more
doaj +1 more source