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Enhanced Nitrosourea Cytotoxicity in Cell Culture by Sodium Butyrate

Oncology, 1985
In HeLa S3 cells, sodium butyrate was found to potentiate the cytotoxicity of chloroethylnitrosoureas and alkylating agents in vitro. Using a soft-agar colony-forming assay, 2.5 and 5.0 mM sodium butyrate pretreatment for 22 h increased the cell killing efficacy of both methyl- and chloroethylnitrosoureas by between 30 and 70%.
V T, Vu, B C, Moy, P S, Schein, K D, Tew
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Dual effects of sodium butyrate on hepatocellular carcinoma cells

Molecular Biology Reports, 2012
Sodium butyrate (NaBu), a histone deacetylase inhibitor, has been shown to inhibit cell growth, induce cell differentiation and apoptosis in multiple cell lines. In present study, we revealed the dual effects of NaBu in regulating hepatocellular carcinoma (HCC) cells.
Wenjun, Jiang +11 more
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Apoptosis of bladder cancer by sodium butyrate and cisplatin

Journal of Infection and Chemotherapy, 2012
The effects of sodium butyrate (SB), a histone deacetylase inhibitor, in combination with cisplatin (CDDP), for inhibition of cell growth and induction of apoptosis were investigated in bladder cancer cell lines in vitro. Bladder cancer cell lines T24, 253J, and UMUC3 were treated with different concentrations of CDDP or SB.
Takuo, Maruyama +6 more
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Sodium butyrate ameliorates the cognitive impairment of Alzheimer’s disease by regulating the metabolism of astrocytes