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Sodium butyrate induced keratinocyte apoptosis
Apoptosis, 2006Apoptosis of keratinocytes is a key mechanism required for epidermal homeostasis and the renewal of damaged cells. Its dysregulation has been implicated in many skin diseases including cancer and hyperproliferative disorders. In the present study, the effect of sodium butyrate, a histone deacetylase inhibitor, on keratinocyte apoptosis was investigated
Timothy E. Rayner +7 more
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Regulation of Neutrophil Apoptosis by Sodium Butyrate
Biologicals, 1996Neutrophils have a very short half life because they constitutively undergo apoptosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) can delay apoptosis, but this agent also primes functions such as the respiratory burst and receptor upregulation.
C. A. Hart +4 more
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The effect of sodium butyrate on histone modification
Cell, 1978The hyperacetylation of histones due to treatment of cultured cells with sodium butyrate has been studied. The hyperacetylation is due to inhibition of histone deacetylase. Other short chain fatty acids including acetic, isobutyric and propionic acid also produce increased modification.
Roger Chalkley, Linda Sealy
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Cancer Chemotherapy and Pharmacology, 1999
To define the plasma concentrations of butyrate achieved and the profile of plasma butyrate concentrations versus time in mice and rats treated with tributyrin or sodium butyrate.Female CD2F1 mice were treated with tributyrin by oral gavage or with sodium butyrate by i.v. bolus or oral gavage. Oral tributyrin doses delivered to mice were 3.1, 5.2, 7.8,
Merrill J. Egorin +4 more
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To define the plasma concentrations of butyrate achieved and the profile of plasma butyrate concentrations versus time in mice and rats treated with tributyrin or sodium butyrate.Female CD2F1 mice were treated with tributyrin by oral gavage or with sodium butyrate by i.v. bolus or oral gavage. Oral tributyrin doses delivered to mice were 3.1, 5.2, 7.8,
Merrill J. Egorin +4 more
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Sleep induced by sodium butyrate in the cat
Brain Research, 1967Summary The para-sleep inducing effect of sodium butyrate and related compounds was studied polygraphically in 45 cats with implanted electrodes. The intravenous administration of sodium butyrate (1.5–3mM/kg) induced the para-sleep phase. This phase appeared after a 2–6 min period of induced ortho-sleep, and continued for 3–10 min.
Hiromu Takagi, Masaji Matsuzaki
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Effect of sodium butyrate on chromatin structure
Biochemical and Biophysical Research Communications, 1980Abstract Sodium butyrate is able to modify gene expression. It was then interesting to study its effect on chromatin structure. Butyrate modified the accessibility of chromatin from HTC cells to micrococcal nuclease : chromatin was digested to a higher rate until 1.5 % of the DNA was rendered acid soluble, in longer digestion it was attacked to a ...
Lydie Tichonicky +3 more
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Effect of sodium butyrate on the granulopoiesis of mastocytoma cells
Experimental Cell Research, 1979Abstract The effect of sodium butyrate on mastocytoma p-815-4 cells was examined. In the presence of butyrate, the proliferation of mastocytoma p-815-4 cells decreased without any detectable cellular degeneration, and the average cell volume of the butyrate-treated cells increased.
H. Akedo +4 more
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Apoptosis of bladder cancer by sodium butyrate and cisplatin
Journal of Infection and Chemotherapy, 2012The effects of sodium butyrate (SB), a histone deacetylase inhibitor, in combination with cisplatin (CDDP), for inhibition of cell growth and induction of apoptosis were investigated in bladder cancer cell lines in vitro. Bladder cancer cell lines T24, 253J, and UMUC3 were treated with different concentrations of CDDP or SB.
Shingo Yamamoto +6 more
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Effect of sodium butyrate on myoblast growth and differentiation
Biochemical and Biophysical Research Communications, 1979Abstract Myoblasts from L6 line, after a period of cell division, undergo differentiation into large multinucleated syncitia in 8–9 days. Butyrate was added for 24 hours at various times of culture. In all samples growth was strongly inhibited. After removal of butyrate, growth continued at the same rate for 2 days, afterwards the growth rate became ...
Jacques Kruh, Marie-Pierre Leibovitch
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Induction of cellular transglutaminase biosynthesis by sodium butyrate
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1987Cellular transglutaminase activity was induced in simian virus-transformed human embryonic lung fibroblasts (WI-38 VA13A) by sodium butyrate. The level of enzyme activity approached a maximum by 6 days; 9-11-fold higher in the presence of sodium butyrate (1 mM) than in its absence.
Merle D. Maxwell +4 more
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