Results 181 to 190 of about 2,084,616 (297)

Decreasing Microtubule Detyrosination Improves Cardiac Mechanics and Sodium Channel Function in Arrhythmogenic Cardiomyopathy. [PDF]

Circ Arrhythm Electrophysiol
Nasilli G, Lin X, Swiatlowska P, Meraviglia V, Pérez-Hernández M, Zhang M, Sanchez-Alonso JL, Bellin M, Gorelik J, Rothenberg E, Casini S, Delmar M, Remme CA.   +12 more
europepmc   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Compensatory rearrangement of parvalbumin interneuron voltage-gated sodium channel subunits in a mouse model of Dravet syndrome. [PDF]

Epilepsia
Dabrowski AK, Somarowthu A, Liebergall SR, Lorenzo DN, Goldberg EM.   +4 more
europepmc   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Sodium Channel [PDF]

, 2020
openaire   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability. [PDF]

Circ Res
Clark CJ, Anderson CE, Dou A, Dierdorff JM, Galpin JD, Gissot L, Thompson SG, Choi H, Yoon JY, Infield DT, McLendon JM, Hoeger JM, Rabab'h O, Bronk P, Leeds K, Kutschke WJ, Paradee WJ, Boudreau RL, Choi BR, London B, Ahern CA.   +20 more
europepmc   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Ventricular conduction is a marker for arrhythmic risk in SCN5A-E1784K overlap sodium channel disease. [PDF]

Europace
Tanck MWT, Wijeyeratne YD, Barc J, Muir A, Aiba T, Bos JM, Veltmann C, Galvin J, Crotti L, Ishikawa T, Ohno S, Page SP, Denjoy I, Tester DJ, Muggenthaler M, Takahashi K, Raju H, Gourraud JB, Redon R, Schott JJ, Haglund-Turnquist C, Pedrazzini M, Alberio C, Dagradi F, Papadakis M, Sharma S, Petzer E, Roden DM, Horie M, Schwartz PJ, Makita N, Borggrefe MM, Ackerman MJ, Shimizu W, McKeown PP, Probst V, Behr ER.   +36 more
europepmc   +1 more source