Results 231 to 240 of about 51,216 (289)
Sodium channel blockers for neuropathic pain [PDF]
Expert Opinion on Therapeutic Patents, 2010 The voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability and their abnormal activity is related to several pathological processes, including cardiac arrhythmias, epilepsy, neurodegenerative diseases, spasticity, chronic and neuropathic pain. In particular, neuropathic pain (e.g., postherpetic and trigeminal
ZULIANI, Valentina +3 more
openaire +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Dibenzazepines and dibenzoxazepines as sodium channel blockers
Bioorganic and Medicinal Chemistry Letters, 2015We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Laykea Tafesse
exaly +3 more sources
Epilepsy and sodium channel blockers
Expert Opinion on Therapeutic Patents, 2002Epilepsy is one of the most frequent neurological diseases and although most patients nowadays respond well to anti-epileptic drugs (AED), 30 - 40% of them still present seizures despite treatment ...
Daniel Bertrand
exaly +2 more sources
Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers [PDF]
Expert Opinion on Investigational Drugs, 2020 Introduction: Neuropathic pain is a chronic condition that significantly affects the quality of life of millions of people globally. Most of the pharmacologic treatments currently in use demonstrate modest efficacy and over half of all patients do not ...
Nebojsa Nick Knežević
exaly +2 more sources
Journal of Medicinal Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
openaire +2 more sources
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
openaire +2 more sources
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents [PDF]
European Journal of Medicinal Chemistry, 2008 1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel ...
Michela De Bellis +2 more
exaly +2 more sources
Sodium Channel Blockers in Neuropathic Pain
Current Pharmaceutical Design, 2005Subtypes of tetrodotoxin resistant voltage-gated sodium channels are involved in the development of certain types of neuropathic pains. After nerve injury hyperexcitability and spontaneous firing develop at the site of injury and also in the dorsal root ganglion cell bodies.
openaire +2 more sources
Metaflumizone is a novel sodium channel blocker insecticide
Veterinary Parasitology, 2007Metaflumizone is a novel semicarbazone insecticide, derived chemically from the pyrazoline sodium channel blocker insecticides (SCBIs) discovered at Philips-Duphar in the early 1970s, but with greatly improved mammalian safety. This paper describes studies confirming that the insecticidal action of metaflumizone is due to the state-dependent blockage ...
V L, Salgado, J H, Hayashi
openaire +2 more sources
Sodium Channel Blockers in the Treatment of Epilepsy
CNS Drugs, 2017Sodium channel blockers have been the mainstay of the pharmacological management of focal and generalised tonic-clonic seizures for more than 70 years. The focus of this paper will be on phenytoin, carbamazepine, lamotrigine, oxcarbazepine, rufinamide, lacosamide and eslicarbazepine acetate. All these antiepileptic drugs have similar efficacy and share
openaire +2 more sources
Polymorphism of a Novel Sodium Ion Channel Blocker
Journal of Pharmaceutical Sciences, 20032-[[4-(4-Fluorophenoxy)phenyl]-methylene]-hydrazinecarboxamide, a member of the semicarbazone family which has shown potential therapeutic use as anticonvulsants, has been found to exist in two polymorphic forms denoted A and B. In addition to reporting aspects of the physical characterization of both forms, the crystal structure of polymorph A has ...
Eugene Y, Cheung +4 more
openaire +2 more sources