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Cardiac Sodium Channel Diseases
Clinical Chemistry and Laboratory Medicine, 2003In the last few years, a very active line of research took place after the first identification of SCN5A mutations associated with an inherited form of cardiac arrhythmias and sudden death, the LQT3 variant of the long QT syndrome. Subsequently, two allelic diseases additional to LQT3 were shown to be due to mutations in the same gene, the Brugada ...
Napolitano,C, Rivolta, I, Priori, SG
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2017
Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
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Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
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Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Epithelial Sodium Channels (ENaCs)
2015Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Epithelial Sodium Channel: A Ligand-Gated Channel?
Nephron Physiology, 2004The epithelial sodium channel (ENaC) is a key component of the transepithelial Na<sup>+</sup> transport. In epithelia, it is responsible for the maintenance of Na<sup>+</sup> balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of
Jean-Daniel, Horisberger +1 more
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Introduction to Sodium Channels
2014Voltage-gated sodium channels (VGSCs) are present in many tissue types within the human body including both cardiac and neuronal tissues. Like other channels, VGSCs activate, deactivate, and inactivate in response to changes in membrane potential.
Colin H, Peters, Peter C, Ruben
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2015
Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour.
Abdella M, Habib +2 more
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Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour.
Abdella M, Habib +2 more
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Tetrodotoxin-resistant sodium channels
Cellular and Molecular Neurobiology, 19941. Tetrodotoxin (TTX) has been widely used as a chemical tool for blocking Na+ channels. However, reports are accumulating that some Na+ channels are resistant to TTX in various tissues and in different animal species. Studying the sensitivity of Na+ channels to TTX may provide us with an insight into the evolution of Na+ channels. 2.
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Neurology, 2007
Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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