Results 41 to 50 of about 4,509 (135)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available ...
Abbracchio, MP, Al-Hosaini, K, Aldrich, R, Alexander, SPH, Arumugam, TV, Attali, B, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Bettler, B, Biel, M, Birdsall, NJ, Blaho, V, Boison, D, Bryant, C, Bräuner-osborne, H, Bröer, S, Buneman, OP, Burnstock, G, Bäck, M, Calo, G, Catterall, WA, Ceruti, S, Chan, SL, Chandy, KG, Chazot, P, Chiang, N, Christopoulos, A, Chun, JJ, Chung, JJ, Cidlowski, JA, Clapham, DE, Clapp, L, Connor, MA, Cox, HM, Davenport, AP, Davies, JA, Davies, P, Dawson, PA, Decaen, P, Dent, G, Doherty, P, Douglas, SD, Dubocovich, ML, Fabbro, D, Faccenda, E, Fong, TM, Fowler, CJ, Frantz, A, Fuller, P, Fumagalli, M, Futerman, AH, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Goudet, C, Gregory, K, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hamann, J, Hammond, JR, Hancox, JC, Hanson, J, Hanukoglu, I, Harding, SD, Hay, DL, Hobbs, AJ, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Irving, AJ, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, MF, Jensen, R, Jockers, R, Kaczmarek, LK, Kanai, Y, Karnik, S, Kellenberger, S, Kelly, E, Kemp, S, Kennedy, C, Kerr, ID, Kihara, Y, Kukkonen, J, Larhammar, D, Marrion, NV, Pawson, AJ, Peters, JA, Sharman, JL, Southan, C, Spedding, M, Striessnig, J   +99 more
core  

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 [PDF]

, 2014
The hydantoin transporter Mhp1 is a sodium-coupled secondary active transport protein of the nucleobase-cation-symport family and a member of the widespread 5-helix inverted repeat superfamily of transporters.
A Peter Johnson, Alexander D Cameron, Colin WG Fishwick, David Drew, David J Sharples, Ekaterina Ivanova, Florian Brueckner, Joseph Lanigan, Katie J Simmons, Mark SP Sansom, Oliver Beckstein, Peter JF Henderson, Scott M Jackson, Simon G Patching, Simone Weyand, So Iwata, Tian Geng, Zsoldos Z   +17 more
core   +4 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Deciphering the Sodium Sensing Mechanisms in Glycophytes and Halophytes

Plant, Cell &Environment, Volume 48, Issue 12, Page 8586-8603, December 2025.
ABSTRACT Plants, including halophytes (salt‐tolerant) and glycophytes (salt‐sensitive), have developed diverse molecular mechanisms and morphological adaptations to survive in saline environments. The cellular components and molecular processes for salinity sensing and stress tolerance have been extensively identified in glycophytes, but not so with ...
Rabia Areej Cheema, Hafiz Mamoon Rehman, Sehar Nawaz, Shakeel Ahmad, Hon‐Ming Lam   +4 more
wiley   +1 more source

Evaluation of Goitrogenic Content of Common Vegetables in South West Nigeria [PDF]

, 2018
Endemic goiter and associated iodine deficiency disorders (IDD) are prevalent in south west Nigeria. The present study was undertaken to identify the role of dietary goitrogen in the etiology of endemic goiter.
Jaiyesimi, Kikelomo Folake, Kolawole, Jesumiluyi Augustine, Okesola, Mary Abiola, Oladejo, Afees Adebayo, Oyerinde, Adebowale Samuel   +4 more
core   +2 more sources

Genomic and non-genomic effects of a new sodium-sensing network in renal and lung epithelia [PDF]

, 2012
Sodium and water homeostasis is crucial for cell function, survival and health of the individual. The kidney is responsible for sodium regulation in the body, balancing sodium secretion and reabsorption, and thereby also regulating the blood pressure,
Eneling, Kristina
core   +1 more source

Construction of a Fluorescence‐Based Logic Gate Seeing the Effect of Perchlorate Ions on Hemicyanine Dye–β‐Cyclodextrin Complexes to Certify Safe Drinking Water

ChemistryOpen, Volume 14, Issue 10, October 2025.
A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M., Shalini Dyagala, Sairathna Choppella, Mahesh Kumar Ravva, Subit Kumar Saha   +4 more
wiley   +1 more source

The betaine/GABA transporter and betaine: roles in brain, kidney, and liver [PDF]

, 2014
The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium symporter transporter family) and mediates cellular uptake of betaine and GABA ...
Niels C. Danbolt, Stephen A. Kempson, Yun Zhou   +2 more
core   +2 more sources

Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein–Protein Interaction

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study explores the genetic overlap among PTSD, MDD, BD, and SZ, revealing shared biological pathways and co‐expression networks. Functional enrichment analysis highlights common molecular mechanisms underlying these psychiatric disorders, providing insights into their comorbidity and potential avenues for targeted therapeutic strategies.
Hernan F. Guillen‐Burgos, Valentina Vanegas, Isabella Gonzalez, Ana M. Caicedo, Valentina Arango, Juan F. Galvez‐Florez, Juan‐Manuel Anaya, Roger S. McIntyre, Wilson Terán   +8 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source