Results 31 to 40 of about 4,527 (133)
Aquaporins: important but elusive drug targets. [PDF]
, 2014 The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients.A Bergamo, A Burykin, A Kimura, A Rossi, A Warth, A Warth, AB Chepelinsky, AJ Smith, AJ Yool, AJ Yool, Alan S. Verkman, AP Martins, AP Martins, AS Verkman, AS Verkman, B Bassarak, B Bertrand, B Ma, B Yang, B Yang, B Yang, B Yang, B Zhang, BC Kieseier, BJ Baum, BJ Baum, BJ Jin, BK Tamarappoo, BL de Groot, C Esteva-Font, C Goubau, C Maurel, CL Chou, CM Niemietz, D Fu, D Fu, D Seeliger, D Wesche, D Zhang, DC Blaydon, DG Bichet, DK Binder, DM Wingerchuk, E Beitz, E Lindahl, E Migliati, E Solenov, E Soupene, EM Muller, EM Nagy, ET Olesen, EW Miller, F Baumgart, FJ Detmers, G Di Giusto, G Fischer, G Soveral, G Soveral, GM Preston, GM Preston, GP Bienert, GP Nicchia, GT Manley, H Chen, H Hasegawa, H Sui, H Tsukaguchi, H Zhang, HJ Jung, HL Brooks, J Badaut, J Farinas, J Farinas, J Farinas, J Gao, J Hu, J Li, J Li, J Liu, J Palace, J Schnermann, JD Ho, JE Rash, JF Kun, JJ Iliff, JJ Irwin, JL Edelman, JM Crane, JP Morello, JR Thiagarajah, JS Hub, K Ishibashi, K Miranda, K Murata, K Oshio, K Oshio, K Oshio, KI Auguste, L Janosi, L Tradtrantip, L Tradtrantip, L Tradtrantip, L Tradtrantip, LJ Galietta, LM Holm, LS King, M Amiry-Moghaddam, M Araki, M Boone, M Dumas, M Endo, M Hara, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Herrera, M Kato, M Moore, M Ozu, M Ozu, Marc O. Anderson, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MG Mola, MH Levin, MH Levin, MJ Tait, MP Marrades, N Chihara, N Maeda, N Roudier, N Roudier, N Zhu, NN Haj-Yasein, O Bloch, O Bloch, P Padmawar, PM Deen, PW Phuan, R Gao, R Katada, R Musa-Aziz, R Zhang, RB Zhang, RI Macey, S Jelen, S Jelen, S Nielsen, S Nielsen, S Pavlovic-Djuranovic, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Sasaki, S Tornroth-Horsefield, SD Shields, SJ Wacker, SR Hinson, SR Hinson, T Gonen, T Hibuse, T Ma, T Ma, T Ma, T Ma, T Ma, T Yamamoto, T Zeuthen, TH Kwon, TL Pallone, V Berry, VA Lennon, VA Lennon, VJ Huber, VJ Huber, W Castro-Borges, X Cao, Y Liu, Y Morishita, Y Song, Y Song, Y Wang, YB Zhang, YH Huang, Z Zhang, ZH Li +194 morecore +1 more sourceTHE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available ...Abbracchio, MP, Al-Hosaini, K, Aldrich, R, Alexander, SPH, Arumugam, TV, Attali, B, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Bettler, B, Biel, M, Birdsall, NJ, Blaho, V, Boison, D, Bryant, C, Bräuner-osborne, H, Bröer, S, Buneman, OP, Burnstock, G, Bäck, M, Calo, G, Catterall, WA, Ceruti, S, Chan, SL, Chandy, KG, Chazot, P, Chiang, N, Christopoulos, A, Chun, JJ, Chung, JJ, Cidlowski, JA, Clapham, DE, Clapp, L, Connor, MA, Cox, HM, Davenport, AP, Davies, JA, Davies, P, Dawson, PA, Decaen, P, Dent, G, Doherty, P, Douglas, SD, Dubocovich, ML, Fabbro, D, Faccenda, E, Fong, TM, Fowler, CJ, Frantz, A, Fuller, P, Fumagalli, M, Futerman, AH, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Goudet, C, Gregory, K, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hamann, J, Hammond, JR, Hancox, JC, Hanson, J, Hanukoglu, I, Harding, SD, Hay, DL, Hobbs, AJ, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Irving, AJ, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, MF, Jensen, R, Jockers, R, Kaczmarek, LK, Kanai, Y, Karnik, S, Kellenberger, S, Kelly, E, Kemp, S, Kennedy, C, Kerr, ID, Kihara, Y, Kukkonen, J, Larhammar, D, Marrion, NV, Pawson, AJ, Peters, JA, Sharman, JL, Southan, C, Spedding, M, Striessnig, J +99 morecore Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)
American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.ABSTRACT
This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...Piero Leone, Alessia Nisco, Luciana de Gennaro, Maria Tolomeo, Elisa Lorefice, Giuseppe Petrosillo, Silvia Russo, Donatella De Giovanni, Claudia Rita Catacchio, Francesca Romana Lepri, Mario Ventura, Simonetta Simonetti, Albina Tummolo, Maria Barile +13 morewiley +1 more sourcePolysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment [PDF]
, 2016 Polysialic acid (polySia) is a unique carbohydrate polymer expressed on the surface of NCAM (neuronal cell adhesion molecule) in a number of cancers where it modulates cell-cell and cell-matrix adhesion, migration, invasion and metastasis and is strongly A Le, A Nagelkerke, A Sermeus, A Tate, AE Greijer, AL Harris, AR Padhani, B Revilla-Nuin, B Revilla-Nuin, CA Grant, CC Liang, CJ Hu, CJ Yeom, D Figarella-Branger, DM Gilkes, F Freiberger, F Guan, F Tanaka, F Tanaka, G Lahr, G Powis, GL Semenza, GL Semenza, H Hildebrandt, I Fujimoto, J Li, J Roth, J Trouillas, JE Ziello, JM Brown, JP Piret, JR Sierra, JV Joseph, KJ Livak, M Hockel, M Kunz, M Maftouh, M Suzuki, MY Koh, NC Denko, P Fardin, P Komminoth, P Subarsky, P Vaupel, PI Johansson, R Airley, R Seidenfaden, RA Blaheta, RA Falconer, S Inoue, S Jiang, S Nishimura, SJ Allison, SL Organ, SM Elkashef, SS Pinho, T Han, TD Ardyanto, U Valentiner, VR Fantin, WG An, X Wang, YM Al-Saraireh +62 morecore +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri +51 morewiley +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri +28 morewiley +1 more sourceThe Rotavirus Enterotoxin NSP4 Directly Interacts with the Caveolar Structural Protein Caveolin-1 [PDF]
, 2006 Rotavirus nonstructural protein 4 (NSP4) is known to function as an intracellular receptor at the endoplasmic reticulum (ER) critical to viral morphogenesis and is the first characterized viral enterotoxin.Ball, Judith M., McIntosh, Avery, Mir, Kiran D., Mitchell, DeAnne M., Parr, Rebecca D., Storey, Stephen M., Zhou, Minglong +6 morecore +2 more sourcesDeciphering the Sodium Sensing Mechanisms in Glycophytes and Halophytes
Plant, Cell &Environment, Volume 48, Issue 12, Page 8586-8603, December 2025.ABSTRACT
Plants, including halophytes (salt‐tolerant) and glycophytes (salt‐sensitive), have developed diverse molecular mechanisms and morphological adaptations to survive in saline environments. The cellular components and molecular processes for salinity sensing and stress tolerance have been extensively identified in glycophytes, but not so with ...Rabia Areej Cheema, Hafiz Mamoon Rehman, Sehar Nawaz, Shakeel Ahmad, Hon‐Ming Lam +4 morewiley +1 more sourceChanges in small intestinal homeostasis, morphology, and gene expression during rotavirus infection of infant mice [PDF]
, 2003 Rotavirus is the most important cause of infantile gastroenteritis. Since
in vivo mucosal responses to a rotavirus infection thus far have not been
extensively studied, we related viral replication in the murine small
intestine to ...Boshuizen, J.A. (Jos), Büller, H.A. (Hans), Dekker, J. (Jan), Einerhand, A.W.C. (Sandra), Ham, V.J. van, Koopmans D.V.M., M.P.G. (Marion), Korteland-van Male, A.M. (Anita), Reimerink, J.H. +7 morecore +3 more sources
