Results 11 to 20 of about 2,016 (98)

Radioiodination of Two Carborane-Based Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation. [PDF]

Chembiochem
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Schädlich J, Ullrich M, Haase-Kohn C, Wodtke R, Braun S, Molitor M, Hofmann B, Steinhilber D, Kopka K, Hey-Hawkins E, Pietzsch J, Laube M.   +11 more
europepmc   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Structural, mechanistic and pharmacological studies of inhibitory neurotransmitter transporters

, 2021
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS). The synaptic levels of GABA are controlled by the activity of GABA transporters (GATs) present in the presynaptic and glial membranes.
Joseph, Deepthi
core  

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

From extracellular entry to intracellular release: A water‐assisted transport cycle for creatine in SLC6A8

Protein Science, Volume 35, Issue 7, July 2026.
Abstract The creatine transporter (CRT/SLC6A8) plays a key role in cellular energy homeostasis, yet the molecular mechanism underlying creatine transport remains poorly understood. Here, we reconstruct the complete transport cycle of human CRT using a hybrid simulation strategy that combines constant‐force steered molecular dynamics (cf‐sMD) with ...
Pitambar Poudel, Shailesh Kumar Panday, Emil Alexov   +2 more
wiley   +1 more source

The Ca2+‐CAMTA6‐PP2C49‐HKT1;1 signaling axis modulates ion homeostasis during Arabidopsis seed germination under salt stress

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Soil salinization severely constrains seedling establishment by disrupting cellular Na+/K+ homeostasis. Calcium (Ca2+) signaling contributes to the re‐establishment of ion balance during early growth, yet the mechanisms linking Ca2+ perception to ion transport regulation remain unclear.
Yvonne Kiere, Ancy E. J. Chandran, Guy Sobol, Omer Cremer, Shaked Azoulay‐Portal, Yonatan Wexler, Doron Shkolnik   +6 more
wiley   +1 more source

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, giving rise to plastids in algae and plants. To cope with low atmospheric CO2 concentrations that developed over the course of evolution,
Erik Zimmer, Carolin Poppitz, Stephan Klähn, Khaled A. Selim   +3 more
wiley   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

Data mining methods for the prediction of intestinal absorption using QSAR [PDF]

, 2014
Oral administration is the most common route for administration of drugs. With the growing cost of drug discovery, the development of Quantitative Structure-Activity Relationships (QSAR) as computational methods to predict oral absorption is highly ...
Newby, Danielle Anne
core