Results 11 to 20 of about 1,995 (92)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone, Alessia Nisco, Luciana de Gennaro, Maria Tolomeo, Elisa Lorefice, Giuseppe Petrosillo, Silvia Russo, Donatella De Giovanni, Claudia Rita Catacchio, Francesca Romana Lepri, Mario Ventura, Simonetta Simonetti, Albina Tummolo, Maria Barile   +13 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Deciphering the Sodium Sensing Mechanisms in Glycophytes and Halophytes

Plant, Cell &Environment, Volume 48, Issue 12, Page 8586-8603, December 2025.
ABSTRACT Plants, including halophytes (salt‐tolerant) and glycophytes (salt‐sensitive), have developed diverse molecular mechanisms and morphological adaptations to survive in saline environments. The cellular components and molecular processes for salinity sensing and stress tolerance have been extensively identified in glycophytes, but not so with ...
Rabia Areej Cheema, Hafiz Mamoon Rehman, Sehar Nawaz, Shakeel Ahmad, Hon‐Ming Lam   +4 more
wiley   +1 more source

Construction of a Fluorescence‐Based Logic Gate Seeing the Effect of Perchlorate Ions on Hemicyanine Dye–β‐Cyclodextrin Complexes to Certify Safe Drinking Water

ChemistryOpen, Volume 14, Issue 10, October 2025.
A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M., Shalini Dyagala, Sairathna Choppella, Mahesh Kumar Ravva, Subit Kumar Saha   +4 more
wiley   +1 more source

Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein–Protein Interaction

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study explores the genetic overlap among PTSD, MDD, BD, and SZ, revealing shared biological pathways and co‐expression networks. Functional enrichment analysis highlights common molecular mechanisms underlying these psychiatric disorders, providing insights into their comorbidity and potential avenues for targeted therapeutic strategies.
Hernan F. Guillen‐Burgos, Valentina Vanegas, Isabella Gonzalez, Ana M. Caicedo, Valentina Arango, Juan F. Galvez‐Florez, Juan‐Manuel Anaya, Roger S. McIntyre, Wilson Terán   +8 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source