Results 1 to 10 of about 1,995 (92)

Radioiodination of Two Carborane-Based Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation. [PDF]

Chembiochem
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Schädlich J, Ullrich M, Haase-Kohn C, Wodtke R, Braun S, Molitor M, Hofmann B, Steinhilber D, Kopka K, Hey-Hawkins E, Pietzsch J, Laube M.   +11 more
europepmc   +2 more sources

Co-Administration of Albumin and Furosemide in Acute Heart Failure with Diuretic Resistance

Acta Médica Portuguesa, 2023
Acute heart failure is a frequent cause of hospital admission in Portugal, and has an increasing tendency given the aging population. Although most admissions for acute heart failure are caused by congestive conditions, not all patients have a congestive
Jorge Fernandes, Rita Costa, Renato Guerreiro, Dulce Bonifácio, Ana Rodrigues, Célia Henriques, Patrícia Branco, Inês Araújo, Cândida Fonseca   +8 more
doaj   +1 more source

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.

PLoS Medicine, 2022
BackgroundEpidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk.
James Yarmolinsky, Virginia Díez-Obrero, Tom G Richardson, Marie Pigeyre, Jennifer Sjaarda, Guillaume Paré, Venexia M Walker, Emma E Vincent, Vanessa Y Tan, Mireia Obón-Santacana, Demetrius Albanes, Jochen Hampe, Andrea Gsur, Heather Hampel, Rish K Pai, Mark Jenkins, Steven Gallinger, Graham Casey, Wei Zheng, Christopher I Amos, International Lung Cancer Consortium, PRACTICAL consortium, MEGASTROKE consortium, George Davey Smith, Richard M Martin, Victor Moreno   +25 more
doaj   +1 more source

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj   +1 more source

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Cellular Physiology and Biochemistry, 2014
Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J. Rhoden   +10 more
doaj   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, giving rise to plastids in algae and plants. To cope with low atmospheric CO2 concentrations that developed over the course of evolution,
Erik Zimmer, Carolin Poppitz, Stephan Klähn, Khaled A. Selim   +3 more
wiley   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

A Semi‐Quantitative Yeast Complementation Platform for Characterizing Urea and Ammonia Transport by Membrane Channels

Current Protocols, Volume 6, Issue 3, March 2026.
Abstract Yeast complementation assays provide a robust in vivo platform for characterizing the permeability and pH gating of transmembrane channels. This article details a liquid culture approach to quantify urea and ammonia transport using Saccharomyces cerevisiae deletion strains.
Anna Stoib, Sahar Shojaei, Christine Siligan, Andreas Horner   +3 more
wiley   +1 more source

Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack

New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.
Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos, The Dan Pham, Thibaut Perez, Myriam Ben Amar, Claire Corratgé‐Faillie, François Barbier, Benoit Lacombe   +6 more
wiley   +1 more source