Results 21 to 30 of about 4,527 (133)
The Use of LeuT as a Receptor Model for Antidepressant Development [PDF]
, 2010 Selective serotonin re-uptake inhibitors (SSRIs) have been considered to be promising drugs in psychiatric practice because of their selectivity to serotonin re-uptake transporter (SERT).
Rustanti, L. (Lina)
core
DNA topoisomerases participate in fragility of the oncogene RET [PDF]
, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly +86 more
core +3 more sources
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH [PDF]
, 2015 Although the anti-cancer properties of 3BP have been described previously, its selectivity for cancer cells still needs to be explained. In the work reported here we characterized the kinetic parameters of radiolabelled [14C]-3BP uptake in three breast ...
Ana Preto +50 more
core +1 more source
Current Protocols, Volume 6, Issue 3, March 2026.Abstract Yeast complementation assays provide a robust in vivo platform for characterizing the permeability and pH gating of transmembrane channels. This article details a liquid culture approach to quantify urea and ammonia transport using Saccharomyces cerevisiae deletion strains.
Anna Stoib +3 more
wiley +1 more source
Genomic and non-genomic effects of a new sodium-sensing network in renal and lung epithelia [PDF]
, 2012 Sodium and water homeostasis is crucial for cell function, survival and health of the individual. The kidney is responsible for sodium regulation in the body, balancing sodium secretion and reabsorption, and thereby also regulating the blood pressure,
Eneling, Kristina
core +1 more source
Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack
New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos +6 more
wiley +1 more source
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. [PDF]
, 2016 Acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC) are both members of the ENaC/degenerin family of amiloride-sensitive Na(+) channels.
Alijevic, O. +4 more
core +1 more source
Diseases associated with general amino acid transporters of the solute carrier 6 family (SLC6)
, 2015 Amino acid transporters of the SLC6 family mediate the Na⁺-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs.
Bröer, Stefan
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller +5 more
wiley +1 more source