Molecular theranostics: principles, challenges and controversies
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley +1 more source
Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Da Mu +4 more
core
Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi +6 more
wiley +1 more source
Dietary Salt Levels Affect Salt Preference and Learning in Larval Drosophila [PDF]
Drosophila larvae change from exhibiting attraction to aversion as the concentration of salt in a substrate is increased. However, some aversive concentrations appear to act as positive reinforcers, increasing attraction to an odour with which they have ...
Young, Joanna M. +16 more
core +2 more sources
Effect of salt concentrations on the growth of heat-stressed and unstressed escherichia coli [PDF]
The effect sodium chloride (NaCl) and potassium chloride (KCl) concentration on the growth of Escherichia coli cells cultivated at 37 and 44°C was studied in an effort to understand the importance of the salts and glucose in medium to the growth of E ...
Abdulkarim, S.M. +2 more
core +4 more sources
Electrogenic sodium-bicarbonate cotransport in human ciliary muscle cells [PDF]
We investigated membrane voltage and intracellular pH (pHi) in cultured human ciliary muscle cells using a cell line (H7CM) and primary-cultured human ciliary muscle cells.
Lepple-Wienhues, A. +9 more
core +1 more source
Corrosion of reinforcement in concrete : the effectiveness of organic corrosion inhibitors [PDF]
Includes bibliographical references.Reinforcement corrosion in concrete has presented engineers with the challenge of finding ways of prolonging the service life of structures built in aggressive environments.
Rylands, Thaabit
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Coastal development can alter the salinity fluctuations experienced by tidal creek systems. Understanding how resident organisms, such as the Gulf killifish, respond to these changes is critical, as development along the coastline is projected to triple in the coming decades.
Antrelle D. Clark +3 more
wiley +1 more source
Abstract The creatine transporter (CRT/SLC6A8) plays a key role in cellular energy homeostasis, yet the molecular mechanism underlying creatine transport remains poorly understood. Here, we reconstruct the complete transport cycle of human CRT using a hybrid simulation strategy that combines constant‐force steered molecular dynamics (cf‐sMD) with ...
Pitambar Poudel +2 more
wiley +1 more source
Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells [PDF]
While most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis, a significant number progress to advanced disease exhibiting aggressive clinical characteristics and often becoming refractory to radioactive iodine (RAI ...
Paulo Matos +11 more
core +1 more source

