Results 51 to 60 of about 4,509 (135)

Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib-induced cardiotoxicity [PDF]

, 2018
The tyrosine kinase inhibitor Sunitinib is used to treat cancer and is linked to severe adverse cardiovascular events. Mitogen activated kinase kinase 7 (MKK7) is involved in the development of cardiac injury and is a component of the c-Jun N-terminal ...
Afthab Hussain, Aggarwal, Akat, Babiarz, Bagga, Bello, Boehm, Care, Chang, Christopher Mee, Chu, Di Lorenzo, Doherty, Eaton, Ewer, Faivre, Fenton, Foltz, Force, Fujii, Gerczuk, Gharanei, Ghatalia, Guo, Guttilla, Hahn, Hao, Hardip Sandhu, Hasinoff, Hattori, Hayakawa, He, Helen Maddock, Henderson, Hikoso, Hu, Huang, Huynh, Ichijo, Ilyas, Iriyama, Izumiya, Jia, Kaiser, Karaman, Kataoka, Kataoka, Kataoka, Kataoka, Katoh, Khakoo, Kim, Kim, Kim, Krause, Lavine, Liu, Liu, Luo, Marques, Mima, Mitchell, Mooney, Morita, Nako, Nomura, Pan, Rosenkranz, Roskoski, Saitoh, Samantha Louise Cooper, Sandhu, Sandhu, Schmidinger, Schramek, Shah, Shukla, Song, Song, Sucharov, Sundarrajan, Takeda, Tang, Taniike, Thijs, Thum, Tijsen, Tobiume, Toldo, Volynets, Wang, Wang, Windak, Xiao, Xu, Yamaguchi, Zhang, Zhang   +97 more
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, Volume 12, Issue 29, August 7, 2025.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Acute pancreatitis is inflammation of the pancreas and is most commonly caused by gallstones, alcohol use, hyperlipidemia, or idiopathic. Drug‐induced acute pancreatitis is relatively rare and often under‐recognized; it accounts for 0.1%–2% of all cases. Among many drugs, thiazide diuretics are infrequently implicated but remain a known cause.
Kshitiz Pandey, Ashish Panday, Pratik Pandey, Anand Chaudhary, Sushmita Khanal   +4 more
wiley   +1 more source

Genomics‐assisted breeding for designing salinity‐smart future crops

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3119-3151, August 2025.
This review explores fast‐forward genomics‐assisted breeding tools to fast‐track the designing of salinity‐smart crops. Integration of various breeding tools can enhance salinity tolerance, ensuring sustainable agriculture and global food security. Summary Climate change induces many abiotic stresses, including soil salinity, significantly challenging ...
Ali Raza, Qamar U. Zaman, Sergey Shabala, Mark Tester, Rana Munns, Zhangli Hu, Rajeev K. Varshney   +6 more
wiley   +1 more source

Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy

Physiological Reports, Volume 13, Issue 15, August 2025.
Abstract Pregnancy demands increased food intake and nutrient delivery to support the growing conceptus. The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear. We therefore assessed anatomy and expression of macronutrient transporters in the duodenum, jejunum,
T. Sebastian Overduin, Georgia S. Clarke, Hui Li, Richard L. Young, Kathryn L. Gatford, Amanda J. Page   +5 more
wiley   +1 more source

Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1‐Assisted FA Anion Transport

Acta Physiologica, Volume 241, Issue 7, July 2025.
ABSTRACT Background Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non‐shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduces the proton gradient in the presence of long‐chain fatty acids (FA).
Sanja Vojvodić, Giorgia Roticiani, Mario Vazdar, Elena E. Pohl   +3 more
wiley   +1 more source

Exploring plant tolerance to biotic and abiotic stresses [PDF]

, 2007
Plants are exposed to many stress factors, such as drought, high salinity or pathogens, which reduce the yield of the cultivated plants or affect the quality of the harvested products. Arabidopsis thaliana was used as a model plant to study the responses
Karim, Sazzad
core  

Preemptive iodide treatment in the event of a nuclear disaster: The prepper's guide to the galaxy

Experimental Physiology, Volume 110, Issue 12, Page 1771-1776, December 1, 2025.
Per Karkov Cramon, Søren Holm, Ronan M. G. Berg   +2 more
wiley   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases [PDF]

, 2018
Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized
Carnero Moya, Amancio, García Heredia, José Manuel   +1 more
core   +1 more source