Advanced Science, EarlyView.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
Subicular Astrocytes Govern Seizure‐Impaired Fear Memory
Advanced Science, EarlyView.Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao +15 more
wiley +1 more source
Interaction Study between Umami and Salty Based on Electronic Tongue Technology and σ-τ Model
Shipin gongye ke-jiSalt and salty foods play a crucial role in enhancing flavor and are integral to traditional cuisine. Salt control and intake reduction are particularly important in a sodium reduction policy. To investigate the relationship between umami ingredients and
Linxue DAI +4 more
doaj +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Acta Universitatis Cibiniensis. Series E: Food Technology, 2018 Saccharomyces boulardii, as a probiotic yeast, had been commonly used in food, medicine and feed to treat diarrhea in humans or livestock. However, there are few researches focusing on the preparation of its freeze-drying S.boulardii powder.
Shu Guowei +4 more
doaj +1 more source
COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF INOSINE GLYCYL-CYSTEINYL-GLUTAMATE SODIUM AND ADEMETHIONINE IN THE PREVENTION OF FIBROSIS IN ALCOHOLIC LIVER DISEASE [PDF]
, 2023 Y.V. Orlov +4 more
openalex +1 more source
Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity
Advanced Science, EarlyView.A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee +6 more
wiley +1 more source
Sodium-Stimulated Glutamate Transport in Osmotically Shocked Cells and Membrane Vesicles of Escherichia coli [PDF]
, 1974 Karen M. Miner, Leonard Frank
openalex +1 more source
Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits
Advanced Science, EarlyView.Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu +16 more
wiley +1 more source
Sodium-Dependent Glutamate Uptake by an Alkaliphilic, Thermophilic Bacillus Strain, TA2.A1 [PDF]
, 1999 Catherine J. Peddie +2 more
openalex +1 more source