Results 221 to 230 of about 144,588 (306)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Comparative Analysis of Chemical Composition and Food Safety of Commercial Fish Sauces from Four Asian Countries. [PDF]

Foods
Huang YR, Wu PC, Lo CJ, Lee YC, Tsai YH.
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Study on the processing transformation law of CATR and ATR in Xanthii Fructus and the metabolomics mechanism of their transformation products in LO2 cells. [PDF]

Biochem Biophys Rep
Wang L, Ao H, Huang C, Wu D, Hong Y, Han Y.   +5 more
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The Role of TRPV1 Channel in Cosmetic Safety Evaluation. [PDF]

ACS Omega
Zhang C, Zhou Y, Wang X, Wang F.
europepmc   +1 more source

Comparison of the effectiveness, safety and tolerability of Perampanel and Levetiracetam as monotherapy in Chinese patients with focal‐onset seizures: A single‐center, ambispective, open‐label, real‐world observational study

Epilepsia Open, EarlyView.
Abstract Objective To compare the effectiveness and safety of Perampanel (PER) and Levetiracetam (LEV) as monotherapy in Chinese patients with focal‐onset seizures (FOS). Methods This is a single‐center, ambispective, open‐label, real‐world observational study.
Haiyan Ma, Rui Zhang, Yan Zhang, Honghao Xu, Xuefeng Qu, Yiqing Yang, Jiajia Li, Lu Yang, Qigang Zhou, Haitao Zhu   +9 more
wiley   +1 more source

Beyond Repression: ArsR Functions as a Global Activator of Metabolic and Redox Responses in <i>Escherichia coli</i>. [PDF]

Proteomes
Sather B, Larson J, Hutt Vater K, Westrum J, McDermott TR, Bothner B.   +5 more
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Solute carrier protein family: physiological functions, disease associations, and therapeutic potential in immune-related disorders. [PDF]

Front Immunol
Li P, Liu C, Niu Y, Wu P, Liu L, Jin J, Yang J.   +6 more
europepmc   +1 more source