Postulations for the Migration Behavior of Amino Acids as Cations in Capillary Zone Electrophoresis
ABSTRACT Amino acids (AAs) in their cationic form at pH 2.2 and usual ionic strength show a non‐intuitive migration order in CZE. This is explained by setting up four postulates. The central points in these postulates are the influence of the AA side chain on the pKa${\rm p}K_{\rm a}$ value and the adoption of a defined, preferred conformation to build
Peter Gross+5 more
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Benzodiazepine-resistant epilepsy: unraveling molecular mechanisms and developing multimodal therapeutic strategies. [PDF]
Huang Y, Zhang Y, Liang Y.
europepmc +1 more source
Deletion of Skeletal Muscle Mitochondrial Glutamic-Oxaloacetic Transaminase (GOT2) Enhances Oxaloacetate Inhibition of Succinate Dehydrogenase and Alters Substrate Selectivity. [PDF]
Fink BD, Som R, Yu L, Sivitz WI.
europepmc +1 more source
Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury. [PDF]
Ullrich MM+8 more
europepmc +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Regulation of dendritic cell biology by amino acids and their transporters. [PDF]
Chen S+5 more
europepmc +1 more source
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza+4 more
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The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review. [PDF]
Tanaka R+3 more
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New insights into epileptic spasm generation and treatment from the TTX animal model
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann+2 more
wiley +1 more source