Results 261 to 270 of about 253,651 (355)

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, EarlyView.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, EarlyView.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

Studies on the Use of Loan Extraction to Produce Natural Shower Gels (Cosmetic) Based on Grape Pomace Extracts-The Effect of the Type of Surfactant Borrowed. [PDF]

Molecules
Wasilewski T, Hordyjewicz-Baran Z, Malorna K, Dresler E, Sabura E, Zegarski M, Stanek-Wandzel N.   +6 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Mapping carbon utilization pathways in <i>Histoplasma capsulatum</i> through ¹³C-metabolic flux analysis. [PDF]

mSystems
Heckart A, Cocuron J-C, Ray SC, Matheny GF, Rappleye CA, Alonso AP.   +5 more
europepmc   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

A case report of seizure worsening after perampanel add-on to oxcarbazepine: possible role of metabolic interaction and pharmacogenetics. [PDF]

Front Psychiatry
Fang X, Zhu M, Wang L.
europepmc   +1 more source

The interaction between pain and mental disorders: An interdisciplinary analysis through bibliometrics

Ibrain, EarlyView.
This study elucidates the complex relationship between pain and mental disorders via bibliometric analysis. The left section illustrates neural pathways of pain, while the upper right highlights the link between pain and mental states like anxiety, stress, and sleep disorders, showing their interaction in exacerbating pain perception and persistence ...
Zhimin Tan, Qiyu He, Xian Zhang, Jiarong Feng, Yuxin He, Xiaoqiang Li   +5 more
wiley   +1 more source

Ultrasmall Superparamagnetic Magnetite Nanoparticles as Glutamate-Responsive Magnetic Resonance Sensors. [PDF]

Sensors (Basel)
Mettee H, Asparin A, Ali Z, He S, Li X, Hall J, Kim A, Wu S, Hawker MJ, Uchida M, Wei H.   +10 more
europepmc   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source